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Tbio
ITGAX
Integrin alpha-X

Protein Summary
Description
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268296
  • ENSP00000268296
  • ENSG00000140678

Symbol
  • CD11C
  • CD11C
  • SLEB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
protein domain
0.85
biological term
0.69
cell type or tissue
0.64
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2199.67   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 2147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2199.67   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 2147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
91.7
body mass index
1
1
1
86
1
1
0
1.3
69.1
red blood cell distribution width
4
1
4
37.5
reticulocyte measurement
2
1
2
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
91.7
body mass index
1
86
0
1.3
69.1
red blood cell distribution width
4
37.5
reticulocyte measurement
2
5.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha X
VGNC:5827
454070
Mouse
MGI:96609
16411
Rat
RGD:1561123
499271
Dog
integrin subunit alpha X
VGNC:42135
489929
Horse
integrin subunit alpha X
VGNC:51160
100064779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha X
Mouse
Rat
Dog
integrin subunit alpha X
Horse
integrin subunit alpha X
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20702-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
ECM proteoglycans
Extracellular matrix organization
Hemostasis
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (459)
1 – 10 of 459
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.997
Data Source: Reactome,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.982
Data Source: STRINGDB
CD80
Tclin
Novelty: 0.00031181
Score: 0.975
Data Source: STRINGDB
CLEC4C
Tbio
Novelty: 0.00845053
Score: 0.97
Data Source: STRINGDB
CD33
Tclin
Novelty: 0.00074958
Score: 0.969
Data Source: STRINGDB
LILRB2
Tbio
Novelty: 0.00545569
Score: 0.967
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.966
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.963
Data Source: Reactome,STRINGDB
SIRPA
Tbio
Family: Enzyme
Novelty: 0.0021102
Score: 0.959
Data Source: STRINGDB
CD86
Tclin
Novelty: 0.00029965
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  2199.67

PubMed score by year
PubTator Score  673.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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