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Tclin
ITGAL
Integrin alpha-L

Protein Summary
Description
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356798
  • ENSP00000349252
  • ENSG00000005844
  • ENST00000358164
  • ENSP00000350886

Symbol
  • CD11A
  • CD11A
  • LFA-1
  • LFA1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.8
cellular component
0.72
tissue sample
0.71
disease
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 902.59   (req: < 5)
Gene RIFs: 123   (req: <= 3)
Antibodies: 1879   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 902.59   (req: >= 5)
Gene RIFs: 123   (req: > 3)
Antibodies: 1879   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
lifitegrast
chemical structure image
efalizumab
no chemical structure image available
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
90.8
neutrophil count
1
1
1
77.7
leukocyte count
1
1
1
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
90.8
neutrophil count
1
77.7
leukocyte count
1
56.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha L
VGNC:13720
454045
Macaque
integrin subunit alpha L
711945
Mouse
MGI:96606
16408
Rat
RGD:631424
308995
Dog
integrin subunit alpha L
VGNC:42132
489905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha L
Macaque
integrin subunit alpha L
Mouse
Rat
Dog
integrin subunit alpha L
Protein Structure (39 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20701-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 39
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Extracellular matrix organization
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (297)
1 – 10 of 297
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.999
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.999
Data Source: Reactome,STRINGDB
ICAM3
Tbio
Novelty: 0.00213474
Score: 0.997
Data Source: STRINGDB
ICAM5
Tbio
Novelty: 0.01506377
Score: 0.993
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.98
Data Source: STRINGDB
ICAM2
Tbio
Novelty: 0.00480584
Score: 0.975
Data Source: STRINGDB
ITGB7
Tclin
Novelty: 0.01290005
Score: 0.969
Data Source: STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
Score: 0.967
Data Source: STRINGDB
CD28
Tbio
Novelty: 0.00036482
Score: 0.967
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  902.59

PubMed score by year
PubTator Score  1481.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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