Tclin ITGAL Integrin alpha-L

Protein Summary

Description

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20701
• O43746
• Q45H73
• Q96HB1
• Q9UBC8

Gene Name

• ITGAL

Ensembl ID

• ENST00000356798
• ENSP00000349252
• ENSG00000005844
• ENST00000358164
• ENSP00000350886

Symbol

• CD11A
• CD11A
• LFA-1
• LFA1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
biological process	0.8
cellular component	0.72
tissue sample	0.71
disease	0.67

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 902.59   (req: < 5)

Gene RIFs: 123   (req: <= 3)

Antibodies: 1879   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 902.59   (req: >= 5)

Gene RIFs: 123   (req: > 3)

Antibodies: 1879   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

lifitegrast

ITGALTclin

ANTAGONIST IC50 : 8.04575729

efalizumab

ITGALTclin

ANTIBODY BINDING Kd : 11.4

Active Ligands (72)

Explore Active Ligands

1 – 10 of 72

CHEMBL387737

ITGALTclin

IC50 : 6.02

CHEMBL1222289,CHEMBL1222288

ITGALTclin

IC50 : 6.58

CHEMBL1222132

ITGALTclin

IC50 : 6.26

CHEMBL3298409

ITGALTclin

IC50 : 6.31

CHEMBL1222022

ITGALTclin

IC50 : 6.37

CHEMBL1095148

ITGALTclin

IC50 : 8.22

CHEMBL1094127

ITGALTclin

IC50 : 8.4

CHEMBL3298412

ITGALTclin

IC50 : 6.45

CHEMBL1094431

ITGALTclin

IC50 : 7.58

CHEMBL507237

ITGALTclin

IC50 : 6.52

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	2	2	2		90.8
neutrophil count	EFO_0004833	1	1	1		77.7
leukocyte count	EFO_0004308	1	1	1		56.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	2		90.8
neutrophil count	EFO_0004833	1		77.7
leukocyte count	EFO_0004308	1		56.1

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha L	VGNC:13720	454045
Macaque	integrin subunit alpha L		711945
Mouse	integrin alpha L	MGI:96606	16408
Rat	integrin subunit alpha L	RGD:631424	308995
Dog	integrin subunit alpha L	VGNC:42132	489905

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha L
Macaque	integrin subunit alpha L
Mouse	integrin alpha L
Rat	integrin subunit alpha L
Dog	integrin subunit alpha L

Protein Structure (39 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20701-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 39

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (42)

Reactome (14)

KEGG (11)

PathwayCommons (5)

WikiPathways (12)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Extracellular matrix organization	297 targets	R-HSA-1474244
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (27)

Functions (5)

Components (7)

Processes (15)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
cell adhesion molecule binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
ICAM-3 receptor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (297)

Explore Interacting Targets

1 – 10 of 297

• See Interactions on String-DB

ICAM1

Tchem

Novelty: 0.00009746

Score: 0.999

Data Source: STRINGDB

ITGB2

Tclin

Novelty: 0.00185859

Score: 0.999

Data Source: Reactome,STRINGDB

ICAM3

Tbio

Novelty: 0.00213474

Score: 0.997

Data Source: STRINGDB

ICAM5

Tbio

Novelty: 0.01506377

Score: 0.993

Data Source: STRINGDB

ITGB1

Tclin

Novelty: 0.00055626

Score: 0.98

Data Source: STRINGDB

ICAM2

Tbio

Novelty: 0.00480584

Score: 0.975

Data Source: STRINGDB

ITGB7

Tclin

Novelty: 0.01290005

Score: 0.969

Data Source: STRINGDB

CTLA4

Tclin

Novelty: 0.00012781

Score: 0.967

Data Source: STRINGDB

CD28

Tbio

Novelty: 0.00036482

Score: 0.967

Data Source: STRINGDB

ITGB3

Tclin

Novelty: 0.00067255

Score: 0.965

Data Source: STRINGDB

Publication Statistics

PubMed Score  902.59

PubMed score by year

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PubTator Score  1481.84

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin

GWAS Trait Find Similar Targets

leukocyte count
myeloid white cell count
neutrophil count

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
neoplasm