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Tbio
LMNB1
Lamin-B1

Protein Summary
Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261366
  • ENSP00000261366
  • ENSG00000113368

Symbol
  • LMN2
  • LMNB
  • LMN
  • ADLD
  • LMN2
  • LMNB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.98
transcription factor binding site profile
0.95
hub protein
0.92
interacting protein
0.9
cellular component
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.58   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.58   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
31.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lamin B1
VGNC:4071
462035
Macaque
lamin B1
703575
Mouse
MGI:96795
16906
Rat
RGD:620522
116685
Dog
lamin B1
VGNC:42718
474663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lamin B1
Macaque
lamin B1
Mouse
Rat
Dog
lamin B1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (127)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Breakdown of the nuclear lamina
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Breakdown of the nuclear lamina
Cell Cycle
Protein-Protein Interactions (271)
1 – 10 of 271
GNAI2
Tbio
Novelty: 0.03014729
p_int: 0.79606921
p_ni: 0.20393079
Score: 0.31
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.992
Data Source: STRINGDB
EMD
Tbio
Novelty: 0.00135202
Score: 0.988
Data Source: STRINGDB
SUN1
Tbio
Novelty: 0.00931817
Score: 0.987
Data Source: STRINGDB
SUN2
Tbio
Novelty: 0.01387591
Score: 0.986
Data Source: STRINGDB
SYNE1
Tbio
Novelty: 0.00315473
Score: 0.983
Data Source: STRINGDB
LEMD3
Tbio
Novelty: 0.00579701
Score: 0.982
Data Source: STRINGDB
BANF1
Tbio
Novelty: 0.00092814
Score: 0.981
Data Source: STRINGDB
SYNE2
Tbio
Novelty: 0.01368736
Score: 0.97
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  733.58

PubMed score by year
PubTator Score  174.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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