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Tbio
COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

Protein Summary
Description
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322347
  • ENSP00000317780
  • ENSG00000178741
  • ENST00000564811
  • ENSP00000456386

Symbol
  • VA
  • COX
  • COX-VA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.94
disease perturbation
0.93
transcription factor binding site profile
0.9
co-expressed gene
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.09   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.09   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
65.7
neutrophil percentage of leukocytes
1
1
1
39.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
65.7
neutrophil percentage of leukocytes
1
39.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 5A
VGNC:3562
453750
Macaque
cytochrome c oxidase subunit 5A
692061
Mouse
MGI:88474
12858
Rat
RGD:620607
252934
Dog
cytochrome c oxidase subunit Va
478370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 5A
Macaque
cytochrome c oxidase subunit 5A
Mouse
Rat
Dog
cytochrome c oxidase subunit Va
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P20674-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (227)
1 – 10 of 227
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
p_int: 0.99952621
p_ni: 0.000473791
Score: 0.999
Data Source: BioPlex,STRINGDB
COX7A2L
Tbio
Family: Enzyme
Novelty: 0.06920916
p_int: 0.99926068
p_ni: 0.0007388
p_wrong: 5.21e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
SLC30A9
Tbio
Family: Transporter
Novelty: 0.07156604
p_int: 0.995319715
p_ni: 0.004680285
Score: 0.309
Data Source: BioPlex,STRINGDB
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
p_int: 0.760365726
p_ni: 0.239634274
Score: 0.996
Data Source: BioPlex,STRINGDB
COX7C
Tbio
Family: Enzyme
Novelty: 0.05516787
Score: 0.999
Data Source: STRINGDB
COX6B1
Tbio
Family: Enzyme
Novelty: 0.02531055
Score: 0.999
Data Source: STRINGDB
COX6C
Tbio
Family: Enzyme
Novelty: 0.04365165
Score: 0.999
Data Source: STRINGDB
MT-CO2
Tchem
Family: Enzyme
Novelty: 0.00073921
Score: 0.999
Data Source: STRINGDB
COX5B
Tbio
Family: Enzyme
Novelty: 0.01729026
Score: 0.999
Data Source: STRINGDB
COX6A1
Tbio
Family: Enzyme
Novelty: 0.05543187
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.09

PubMed score by year
PubTator Score  14.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer