Tbio M6PR Cation-dependent mannose-6-phosphate receptor

Protein Summary

Description

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P20645
• A8K528
• D3DUV5
• CD Man-6-P receptor

Gene Name

• M6PR

Ensembl ID

• ENST00000000412
• ENSP00000000412
• ENSG00000003056

Symbol

• MPR46
• MPRD
• SMPR
• MPR46
• CD-MPR
• MPR 46
• MPR-46
• CD-M6PR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
transcription factor perturbation	0.94
cellular component	0.91
transcription factor binding site profile	0.9
histone modification site profile	0.87

Protein Classes

PANTHER Classes

Protein / Receptor / Cation-dependent Mannose-6-phosphate Receptor

DTO Classes

Protein / Receptor / Cation-dependent Mannose-6-phosphate Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.47   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.47   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0