You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MX2
Interferon-induced GTP-binding protein Mx2

Protein Summary
Description
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330714
  • ENSP00000333657
  • ENSG00000183486

Symbol
  • MXB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
molecular function
0.91
PubMedID
0.82
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1122.65   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1122.65   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (208)
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.997
Data Source:  STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
Score:  0.994
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.993
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.991
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.991
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.991
Data Source:  STRINGDB
OAS1
Tbio
Family:  Enzyme
Novelty:  0.00532331
Score:  0.989
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.988
Data Source:  STRINGDB
OAS3
Tbio
Family:  Enzyme
Novelty:  0.02422229
Score:  0.988
Data Source:  STRINGDB
USP18
Tbio
Family:  Enzyme
Novelty:  0.01087689
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
ISG15 antiviral mechanism
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
ISG15 antiviral mechanism
Immune System
Interferon Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
1
1
89.4
blood protein measurement
1
3
3
89.1
2
1
1
1.1
88.7
self reported educational attainment
2
2
2
88.5
3
2
0
1.1
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
89.4
blood protein measurement
3
89.1
1
1.1
88.7
self reported educational attainment
2
88.5
0
1.1
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
MX dynamin like GTPase 2
VGNC:43512
403744
Horse
MX dynamin like GTPase 2
VGNC:20454
100058538
Cow
MX dynamin like GTPase 2
VGNC:50221
280873
Pig
Interferon-induced GTP-binding protein Mx2 [Source:UniProtKB/Swiss-Prot;Acc:A7VK00]
Species
Name
OMA
EggNOG
Inparanoid
Dog
MX dynamin like GTPase 2
Horse
MX dynamin like GTPase 2
Cow
MX dynamin like GTPase 2
Pig
Interferon-induced GTP-binding protein Mx2 [Source:UniProtKB/Swiss-Prot;Acc:A7VK00]
Publication Statistics
PubMed Score 1122.65
PubMed score by year
PubTator Score 227.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title