Tbio MX1 Interferon-induced GTP-binding protein Mx1

Protein Summary

Description

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• P20591
• B2RDA5
• B3KU10
• C9IYV7
• C9J8D6
• C9JN19
• C9JN88
• C9JUL1
• C9JZS6
• D3DSI8
• Q86YP5
• Q96CI3

Gene Name

• MX1

Ensembl ID

• ENST00000398598
• ENSP00000381599
• ENSG00000157601
• ENST00000398600
• ENSP00000381601
• ENST00000455164
• ENSP00000410523
• ENST00000619682
• ENSP00000478441

Symbol

• MX
• MxA
• IFI78
• IFI-78K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.97
molecular function	0.91
biological term	0.86
small molecule perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Hydrolase / Interferon-induced Gtp-binding Protein Mx1

Protein / Enzyme Modulator / G-protein / Small Gtpase / Interferon-induced Gtp-binding Protein Mx1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Interferon-induced Gtp-binding Protein Mx1

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Interferon-induced Gtp-binding Protein Mx1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1697.02   (req: < 5)

Gene RIFs: 155   (req: <= 3)

Antibodies: 454   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1697.02   (req: >= 5)

Gene RIFs: 155   (req: > 3)

Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0