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Tbio
TRH
Pro-thyrotropin-releasing hormone

Protein Summary
Description
As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302649
  • ENSP00000303452
  • ENSG00000170893

Symbol
  • TRF
  • Pro-TRH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.86
biological process
0.83
disease
0.72
chemical
0.59
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1859.77   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1859.77   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
TRHR
Tclin
Family:  GPCR
Novelty:  0.01143992
Score:  0.992
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.99
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.985
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.976
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.97
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.97
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.969
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.967
Data Source:  STRINGDB
HCRT
Tbio
Novelty:  0.00034048
Score:  0.967
Data Source:  STRINGDB
GRP
Tbio
Novelty:  0.00034247
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
11
95.2
BMI-adjusted waist-hip ratio
1
8
8
92.2
waist-hip ratio
1
9
9
92.2
hip circumference
2
8
9
91.4
sex hormone-binding globulin measurement
3
2
3
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
95.2
BMI-adjusted waist-hip ratio
8
92.2
waist-hip ratio
9
92.2
hip circumference
9
91.4
sex hormone-binding globulin measurement
3
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone
VGNC:7135
738789
Mouse
MGI:98823
22044
Rat
RGD:3903
25569
Dog
thyrotropin releasing hormone
VGNC:47797
100855474
Horse
thyrotropin releasing hormone
VGNC:24488
100056248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone
Mouse
Rat
Dog
thyrotropin releasing hormone
Horse
thyrotropin releasing hormone
Publication Statistics
PubMed Score 1859.77
PubMed score by year
PubTator Score 2487.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title