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Tchem
NR1D1
Nuclear receptor subfamily 1 group D member 1

Protein Summary
Description
Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246672
  • ENSP00000246672
  • ENSG00000126368

Symbol
  • EAR1
  • HREV
  • THRAL
  • EAR1
  • hRev
  • THRA1
  • THRAL
  • ear-1
  • REVERBA
  • REVERBalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
virus perturbation
0.96
transcription factor
0.95
transcription factor binding site profile
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 430.83   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 430.83   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
94.4
1
1
0
1.1
54
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
94.4
0
1.1
54
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group D member 1
VGNC:9481
454644
Mouse
MGI:2444210
217166
Rat
RGD:628827
252917
Dog
nuclear receptor subfamily 1 group D member 1
VGNC:43940
100688236
Horse
nuclear receptor subfamily 1 group D member 1
VGNC:20858
100054466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group D member 1
Mouse
Rat
Dog
nuclear receptor subfamily 1 group D member 1
Horse
nuclear receptor subfamily 1 group D member 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20393-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Circadian Clock
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (51)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (56)
1 – 10 of 56
NR1D2
Tchem
Family: NR
Novelty: 0.01394655
p_int: 0.978675871
p_wrong: 0.021324128
Score: 0.897
Data Source: BioPlex,STRINGDB
ARNTL
Tbio
Family: TF
Novelty: 0.00102829
Score: 0.993
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.99
Data Source: Reactome,STRINGDB
CRY2
Tbio
Novelty: 0.00156961
Score: 0.984
Data Source: STRINGDB
BHLHE41
Tbio
Family: TF
Novelty: 0.01015053
Score: 0.981
Data Source: STRINGDB
NPAS2
Tbio
Family: TF
Novelty: 0.00728451
Score: 0.979
Data Source: STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00159625
Score: 0.979
Data Source: STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.943
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
Score: 0.941
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  430.83

PubMed score by year
PubTator Score  83.26

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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