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Tbio
TAC1
Protachykinin-1

Protein Summary
Description
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319273
  • ENSP00000321106
  • ENSG00000006128
  • ENST00000346867
  • ENSP00000289574
  • ENST00000350485
  • ENSP00000289576

Symbol
  • NKA
  • NKNA
  • TAC2
  • NK2
  • NPK
  • NKNA
  • TAC2
  • Hs.2563
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
biological process
0.98
biological term
0.95
gene perturbation
0.94
PubMedID
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15451.05   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15451.05   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
3.7
feeling nervous measurement
1
1
0
6.1
2.5
social interaction measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
3.7
feeling nervous measurement
0
6.1
2.5
social interaction measurement
1
0.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tachykinin precursor 1
VGNC:8767
747650
Macaque
tachykinin precursor 1
697350
Mouse
MGI:98474
21333
Rat
RGD:3807
24806
Dog
tachykinin precursor 1
VGNC:47061
475239
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tachykinin precursor 1
Macaque
tachykinin precursor 1
Mouse
Rat
Dog
tachykinin precursor 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20366-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (56)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (383)
1 – 10 of 383
TACR2
Tchem
Family: GPCR
Novelty: 0.00194306
Score: 0.999
Data Source: Reactome,STRINGDB
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
Score: 0.998
Data Source: Reactome,STRINGDB
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
Score: 0.993
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.992
Data Source: STRINGDB
TAC3
Tchem
Novelty: 0.001685
Score: 0.991
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.988
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.988
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.986
Data Source: STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.985
Data Source: STRINGDB
TRH
Tbio
Novelty: 0.00052673
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  15451.05

PubMed score by year
PubTator Score  5036.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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