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Tbio
RAB5A
Ras-related protein Rab-5A

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273047
  • ENSP00000273047
  • ENSG00000144566
  • ENST00000422242
  • ENSP00000411941

Symbol
  • RAB5
  • RAB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.97
molecular function
0.94
transcription factor binding site profile
0.93
interacting protein
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 633.58   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 687   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 633.58   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 687   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (38)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Membrane Trafficking
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Factors involved in megakaryocyte development and platelet production
Hemostasis
Membrane Trafficking
Metabolism
Gene Ontology Terms (48)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (454)
1 – 10 of 454
RAB5C
Tbio
Family: Enzyme
Novelty: 0.05493596
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00301194
p_int: 0.999998547
p_ni: 0.000001453
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
GDI1
Tbio
Novelty: 0.02210681
p_int: 0.999997732
p_ni: 0.000002268
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
SUN2
Tbio
Novelty: 0.01877097
p_int: 0.99998017
p_ni: 0.00001983
Score: 0.625
Data Source: BioPlex,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.0116075
p_int: 0.999888743
p_ni: 0.000111256
p_wrong: 1e-9
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
RABGGTA
Tbio
Family: Enzyme
Novelty: 0.18518519
p_int: 0.990133648
p_ni: 0.009866352
Score: 0.971
Data Source: BioPlex,STRINGDB
GDI2
Tbio
Novelty: 0.03351296
p_int: 0.964363113
p_ni: 0.035636887
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
RAB2B
Tdark
Family: Enzyme
Novelty: 0.27592248
p_int: 0.961904516
p_ni: 0.038095481
p_wrong: 3e-9
Score: 0.941
Data Source: BioPlex,STRINGDB
TGFA
Tbio
Novelty: 0.00259473
p_int: 0.950513357
p_ni: 0.049486643
Score: 0.229
Data Source: BioPlex,STRINGDB
ATE1
Tbio
Family: Enzyme
Novelty: 0.0119888
p_int: 0.931482024
p_ni: 0.068517976
Score: 0.167
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  633.58

PubMed score by year
PubTator Score  449.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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