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Tbio
RAB5A
Ras-related protein Rab-5A

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273047
  • ENSP00000273047
  • ENSG00000144566
  • ENST00000422242
  • ENSP00000411941

Symbol
  • RAB5
  • RAB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.97
molecular function
0.94
transcription factor binding site profile
0.93
interacting protein
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.28   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 687   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.28   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 687   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
2
3
94.2
mean reticulocyte volume
1
1
1
86
mean corpuscular hemoglobin concentration
1
1
1
82.3
heel bone mineral density
2
2
2
78.7
reticulocyte count
2
1
2
69.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
94.2
mean reticulocyte volume
1
86
mean corpuscular hemoglobin concentration
1
82.3
heel bone mineral density
2
78.7
reticulocyte count
2
69.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB5A, member RAS oncogene family
VGNC:9693
460217
Macaque
RAB5A, member RAS oncogene family
697712
Mouse
MGI:105926
271457
Dog
RAB5A, member RAS oncogene family
VGNC:45291
404008
Horse
RAB5A, member RAS oncogene family
VGNC:22124
100051997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB5A, member RAS oncogene family
Macaque
RAB5A, member RAS oncogene family
Mouse
Dog
RAB5A, member RAS oncogene family
Horse
RAB5A, member RAS oncogene family
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20339-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Membrane Trafficking
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Factors involved in megakaryocyte development and platelet production
Hemostasis
Membrane Trafficking
Metabolism
Gene Ontology Terms (48)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (454)
1 – 10 of 454
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999998547
p_ni:  0.000001453
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999997732
p_ni:  0.000002268
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
SUN2
Tbio
Novelty:  0.01387591
p_int:  0.99998017
p_ni:  0.00001983
Score:  0.625
Data Source:  BioPlex,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999888743
p_ni:  0.000111256
p_wrong:  1e-9
Score:  0.972
Data Source:  BioPlex,Reactome,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.990133648
p_ni:  0.009866352
Score:  0.971
Data Source:  BioPlex,STRINGDB
GDI2
Tbio
Novelty:  0.02861013
p_int:  0.964363113
p_ni:  0.035636887
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.961904516
p_ni:  0.038095481
p_wrong:  3e-9
Score:  0.941
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.950513357
p_ni:  0.049486643
Score:  0.229
Data Source:  BioPlex,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.931482024
p_ni:  0.068517976
Score:  0.167
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  895.28

PubMed score by year
PubTator Score  449.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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