Tbio RAB4A Ras-related protein Rab-4A

Protein Summary

Description

Protein transport. Probably involved in vesicular traffic (By similarity). This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• P20338
• Q5T7P7
• Q9BQ44

Gene Name

• RAB4A

Ensembl ID

• ENST00000366690
• ENSP00000355651
• ENSG00000168118

Symbol

• RAB4
• RAB4
• HRES1
• HRES-1
• HRES-1/RAB4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
molecular function	0.96
kinase perturbation	0.95
virus perturbation	0.95
transcription factor binding site profile	0.87

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.69   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 309   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.69   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0