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Tbio
RAB3B
Ras-related protein Rab-3B

Protein Summary
Description
Protein transport. Probably involved in vesicular traffic (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371655
  • ENSP00000360718
  • ENSG00000169213
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cellular component
0.91
microRNA
0.83
virus perturbation
0.76
biological process
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
30.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB3B, member RAS oncogene family
VGNC:14173
736412
Macaque
RAB3B, member RAS oncogene family
712683
Mouse
MGI:1917158
69908
Rat
RGD:620922
81755
Dog
RAB3B, member RAS oncogene family
VGNC:45283
608161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB3B, member RAS oncogene family
Macaque
RAB3B, member RAS oncogene family
Mouse
Rat
Dog
RAB3B, member RAS oncogene family
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20337-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (130)
1 – 10 of 130
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
p_int: 0.999999992
p_ni: 2e-9
p_wrong: 6e-9
Score: 0.975
Data Source: BioPlex,STRINGDB
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.999798586
p_ni: 0.000201406
p_wrong: 8e-9
Score: 0.334
Data Source: BioPlex,STRINGDB
LAGE3
Tdark
Novelty: 0.02099961
p_int: 0.991208297
p_ni: 0.008158777
p_wrong: 0.000632926
Data Source: BioPlex
RAET1E
Tbio
Novelty: 0.01859274
p_int: 0.990396532
p_ni: 0.007345015
p_wrong: 0.002258454
Data Source: BioPlex
SLC5A8
Tchem
Family: Transporter
Novelty: 0.00892277
p_int: 0.990322313
p_ni: 0.007093363
p_wrong: 0.002584324
Score: 0.159
Data Source: BioPlex,STRINGDB
CST9L
Tdark
Novelty: 0.21941207
p_int: 0.976099729
p_ni: 0.023848576
p_wrong: 0.000051695
Data Source: BioPlex
GRPR
Tchem
Family: GPCR
Novelty: 0.00282511
p_int: 0.969193626
p_ni: 0.007769029
p_wrong: 0.023037344
Data Source: BioPlex
CNDP1
Tbio
Family: Enzyme
Novelty: 0.0102642
p_int: 0.961197419
p_ni: 0.01501117
p_wrong: 0.023791411
Score: 0.186
Data Source: BioPlex,STRINGDB
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.958584048
p_ni: 0.006994724
p_wrong: 0.034421227
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.955728715
p_ni: 0.007412068
p_wrong: 0.036859216
Score: 0.152
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.52

PubMed score by year
PubTator Score  13.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer