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Tbio
RAB3A
Ras-related protein Rab-3A

Protein Summary
Description
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222256
  • ENSP00000222256
  • ENSG00000105649
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
cellular component
0.91
biological process
0.9
histone modification site profile
0.89
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.36   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.36   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
RAB3B
Tbio
Family:  Enzyme
Novelty:  0.02731183
p_int:  0.999999992
p_ni:  2e-9
p_wrong:  6e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
SYTL4
Tbio
Novelty:  0.03934385
p_int:  0.999999571
p_ni:  4.19e-7
p_wrong:  1.1e-8
Score:  0.764
Data Source:  BioPlex,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999965688
p_ni:  0.000034312
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999453493
p_ni:  0.000546506
p_wrong:  1e-9
Score:  0.954
Data Source:  BioPlex,Reactome,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999365211
p_ni:  0.000634768
p_wrong:  2.1e-8
Data Source:  BioPlex
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.998295603
p_ni:  0.001704175
p_wrong:  2.21e-7
Score:  0.793
Data Source:  BioPlex,STRINGDB
RANGRF
Tbio
Family:  Enzyme
Novelty:  0.02750539
p_int:  0.993727833
p_ni:  0.00130058
p_wrong:  0.004971587
Data Source:  BioPlex
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
p_int:  0.987041532
p_ni:  0.012955568
p_wrong:  0.0000029
Score:  0.928
Data Source:  BioPlex,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.985538267
p_ni:  0.014461733
Score:  0.967
Data Source:  BioPlex,Reactome,STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.980576687
p_ni:  0.008786226
p_wrong:  0.010637087
Score:  0.154
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
GABA synthesis, release, reuptake and degradation
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
GABA synthesis, release, reuptake and degradation
Glutamate Neurotransmitter Release Cycle
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
13
18
32
98.2
waist-hip ratio
5
15
17
98.1
waist circumference
1
8
8
93.8
BMI-adjusted waist circumference
3
9
10
92.7
serum alanine aminotransferase measurement
2
2
1
9.8
89.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
32
98.2
waist-hip ratio
17
98.1
waist circumference
8
93.8
BMI-adjusted waist circumference
10
92.7
serum alanine aminotransferase measurement
1
9.8
89.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB3A, member RAS oncogene family
VGNC:7569
455857
Macaque
RAB3A, member RAS oncogene family
719400
Mouse
MGI:97843
19339
Rat
RGD:3528
25531
Dog
RAB3A, member RAS oncogene family
VGNC:45282
484826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB3A, member RAS oncogene family
Macaque
RAB3A, member RAS oncogene family
Mouse
Rat
Dog
RAB3A, member RAS oncogene family
Publication Statistics
PubMed Score 232.36
PubMed score by year
PubTator Score 135.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title