Tbio TNFRSF1B Tumor necrosis factor receptor superfamily member 1B

Protein Summary

Description

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20333
• B1AJZ3
• Q16042
• Q6YI29
• Q9UIH1

Gene Name

• TNFRSF1B

Ensembl ID

• ENST00000376259
• ENSP00000365435
• ENSG00000028137

Symbol

• TNFBR
• TNFR2
• p75
• TBPII
• TNFBR
• TNFR2
• CD120b
• TNFR1B
• TNFR80
• TNF-R75
• p75TNFR
• TNF-R-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.97
disease perturbation	0.95
PubMedID	0.82
phenotype	0.77
disease	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.3   (req: < 5)

Gene RIFs: 368   (req: <= 3)

Antibodies: 896   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.3   (req: >= 5)

Gene RIFs: 368   (req: > 3)

Antibodies: 896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0