You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNFRSF1B
Tumor necrosis factor receptor superfamily member 1B

Protein Summary
Description
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376259
  • ENSP00000365435
  • ENSG00000028137

Symbol
  • TNFBR
  • TNFR2
  • p75
  • TBPII
  • TNFBR
  • TNFR2
  • CD120b
  • TNFR1B
  • TNFR80
  • TNF-R75
  • p75TNFR
  • TNF-R-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
disease perturbation
0.95
PubMedID
0.82
phenotype
0.77
disease
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.3   (req: < 5)
Gene RIFs: 294   (req: <= 3)
Antibodies: 896   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.3   (req: >= 5)
Gene RIFs: 294   (req: > 3)
Antibodies: 896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (324)
TNF
Tclin
Novelty:  0.00001457
Score:  0.999
Data Source:  Reactome,STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
Score:  0.994
Data Source:  STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
Score:  0.983
Data Source:  STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.98
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.98
Data Source:  STRINGDB
LTA
Tbio
Novelty:  0.00100413
Score:  0.977
Data Source:  Reactome,STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.971
Data Source:  STRINGDB
ADAM17
Tchem
Family:  Enzyme
Novelty:  0.00121971
Score:  0.97
Data Source:  STRINGDB
TNFSF11
Tclin
Novelty:  0.00018328
Score:  0.968
Data Source:  STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.965
Data Source:  Reactome,STRINGDB
Pathways (24)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
3
3
83.4
eosinophil count
1
2
2
76.4
tumor necrosis factor receptor II measurement
1
1
1
74.7
blood protein measurement
1
1
1
71.6
asthma
2
1
0
1.2
70.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
3
83.4
eosinophil count
2
76.4
tumor necrosis factor receptor II measurement
1
74.7
blood protein measurement
1
71.6
asthma
0
1.2
70.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 1B
VGNC:7011
457968
Macaque
TNF receptor superfamily member 1B
715454
Mouse
MGI:1314883
21938
Rat
RGD:621238
156767
Dog
TNF receptor superfamily member 1B
VGNC:47663
487437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 1B
Macaque
TNF receptor superfamily member 1B
Mouse
Rat
Dog
TNF receptor superfamily member 1B
Publication Statistics
PubMed Score 745.30
PubMed score by year
PubTator Score 808.57
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title