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Tclin
CHRM3
Muscarinic acetylcholine receptor M3

Protein Summary
Description
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255380
  • ENSP00000255380
  • ENSG00000133019
  • ENST00000615928
  • ENSP00000482377

Symbol
  • HM3
  • PBS
  • EGBRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
molecular function
0.93
biological process
0.89
biological term
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.73   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.73   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1188
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 61
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (61)
clozapine
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chlorpromazine
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olanzapine
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amitriptyline
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thioridazine
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clemastine
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cyproheptadine
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clomipramine
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nortriptyline
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promazine
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Active Ligands (1188)
CHEMBL4128926
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xanomeline
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dosulepin
Rendered image for dosulepin
(S)-dimetindene
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Valethamate Bromide
Rendered image for Valethamate Bromide
Cetylpyridinium Bromide
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Benzethonium Chloride
Rendered image for Benzethonium Chloride
oxotremorine
Rendered image for oxotremorine
CHEMBL3629360
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Protein-Protein Interactions (239)
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
p_int:  0.999999788
p_ni:  3.9e-8
p_wrong:  1.73e-7
Data Source:  BioPlex
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.99999923
p_ni:  7.7e-7
Data Source:  BioPlex
NOCT
Tbio
Novelty:  0.01696096
p_int:  0.999635278
p_ni:  0.000364722
Data Source:  BioPlex
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
p_int:  0.995630811
p_ni:  0.004369189
Score:  0.307
Data Source:  BioPlex,STRINGDB
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.991549564
p_ni:  0.008450432
p_wrong:  4e-9
Data Source:  BioPlex
FARP2
Tbio
Novelty:  0.09590913
p_int:  0.988722114
p_ni:  0.011247175
p_wrong:  0.000030711
Data Source:  BioPlex
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.988349746
p_ni:  0.011650254
Data Source:  BioPlex
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.986966704
p_ni:  0.002093908
p_wrong:  0.010939388
Data Source:  BioPlex
YIPF4
Tdark
Novelty:  0.17862058
p_int:  0.985060761
p_ni:  0.014936763
p_wrong:  0.000002477
Data Source:  BioPlex
GTPBP2
Tbio
Novelty:  0.10282876
p_int:  0.977657033
p_ni:  0.022342811
p_wrong:  1.56e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Acetylcholine regulates insulin secretion (R-HSA-399997)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
80.3
peak expiratory flow
1
1
1
80
heel bone mineral density
1
1
1
69.8
forced expiratory volume
1
1
1
68.8
Hallucinations
1
1
2
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
80.3
peak expiratory flow
1
80
heel bone mineral density
1
69.8
forced expiratory volume
1
68.8
Hallucinations
2
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor muscarinic 3
VGNC:8317
469725
Macaque
cholinergic receptor muscarinic 3
708901
Mouse
MGI:88398
12671
Rat
RGD:2343
24260
Dog
cholinergic receptor muscarinic 3
VGNC:39233
403827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor muscarinic 3
Macaque
cholinergic receptor muscarinic 3
Mouse
Rat
Dog
cholinergic receptor muscarinic 3
Publication Statistics
PubMed Score 123.73
PubMed score by year
PubTator Score 470.73
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title