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Tchem
ALOX5AP
Arachidonate 5-lipoxygenase-activating protein

Protein Classes
Protein Summary
Description
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380490
  • ENSP00000369858
  • ENSG00000132965

Symbol
  • FLAP
  • FLAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
PubMedID
0.79
gene perturbation
0.76
disease
0.72
small molecule perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.14   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.14   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2019
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
zileuton
Rendered image for zileuton
Active Ligands (2019)
1 – 10 of 2019
CHEMBL16596,CHEMBL313489
Rendered image for CHEMBL16596,CHEMBL313489
MK-886
Rendered image for MK-886
CHEMBL539650
Rendered image for CHEMBL539650
CHEMBL538632
Rendered image for CHEMBL538632
diflapolin
Rendered image for diflapolin
CHEMBL1922663
Rendered image for CHEMBL1922663
CHEMBL1922662
Rendered image for CHEMBL1922662
CHEMBL1229205,CHEMBL1210423
Rendered image for CHEMBL1229205,CHEMBL1210423
CHEMBL38958
Rendered image for CHEMBL38958
CHEMBL552567
Rendered image for CHEMBL552567
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
3.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate 5-lipoxygenase activating protein
VGNC:7283
452520
Macaque
arachidonate 5-lipoxygenase activating protein
713170
Mouse
MGI:107505
11690
Rat
RGD:2097
29624
Dog
arachidonate 5-lipoxygenase activating protein [Source:HGNC Symbol;Acc:HGNC:436]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate 5-lipoxygenase activating protein
Macaque
arachidonate 5-lipoxygenase activating protein
Mouse
Rat
Dog
arachidonate 5-lipoxygenase activating protein [Source:HGNC Symbol;Acc:HGNC:436]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20292-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of specialized proresolving mediators (SPMs)
Fatty acid metabolism
Metabolism
Metabolism of lipids
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (89)
1 – 10 of 89
FRA10AC1
Tdark
Novelty:  0.25570773
p_int:  0.92896959
p_ni:  0.070874295
p_wrong:  0.000156115
Score:  0.517
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.997
Data Source:  Reactome,STRINGDB
LTC4S
Tchem
Family:  Enzyme
Novelty:  0.00945951
Score:  0.947
Data Source:  Reactome,STRINGDB
C1orf162
Tdark
Novelty:  4.98517033
Score:  0.769
Data Source:  STRINGDB
MGST3
Tbio
Family:  Enzyme
Novelty:  0.02891864
Score:  0.76
Data Source:  STRINGDB
MGST1
Tbio
Family:  Enzyme
Novelty:  0.00681882
Score:  0.755
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.75
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.746
Data Source:  STRINGDB
LTA4H
Tchem
Family:  Enzyme
Novelty:  0.00505614
Score:  0.734
Data Source:  STRINGDB
LAPTM5
Tbio
Novelty:  0.06809459
Score:  0.728
Data Source:  STRINGDB
Publication Statistics
PubMed Score  589.14

PubMed score by year
PubTator Score  2232.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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