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Tbio
BTF3
Transcription factor BTF3

Protein Summary
Description
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335895
  • ENSP00000338516
  • ENSG00000145741
  • ENST00000380591
  • ENSP00000369965

Symbol
  • NACB
  • NACB
  • BTF3a
  • BTF3b
  • BETA-NAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
virus perturbation
0.92
co-expressed gene
0.89
histone modification site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.13   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.13   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (165)
1 – 10 of 165
NACAD
Tdark
Novelty: 0.46197991
p_int: 0.999999995
p_ni: 5e-9
Score: 0.895
Data Source: BioPlex,STRINGDB
ANK3
Tbio
Novelty: 0.00429246
p_int: 0.99999898
p_ni: 0.00000102
Data Source: BioPlex
NACA2
Tdark
Novelty: 0.02054943
p_int: 0.99999668
p_ni: 7.03e-7
p_wrong: 0.000002616
Score: 0.958
Data Source: BioPlex,STRINGDB
PRIM1
Tbio
Family: Enzyme
Novelty: 0.0530384
p_int: 0.999957544
p_ni: 0.000042456
Data Source: BioPlex
ANK2
Tbio
Novelty: 0.00528351
p_int: 0.999886681
p_ni: 0.000113318
p_wrong: 1e-9
Data Source: BioPlex
PRIM2
Tbio
Family: Enzyme
Novelty: 0.05145449
p_int: 0.999705484
p_ni: 0.000294516
Data Source: BioPlex
MAPK8IP2
Tbio
Family: Enzyme
Novelty: 0.01788453
p_int: 0.999289569
p_ni: 0.000541197
p_wrong: 0.000169234
Data Source: BioPlex
NAA15
Tbio
Family: Enzyme
Novelty: 0.00513055
p_int: 0.999238814
p_ni: 0.000761183
p_wrong: 3e-9
Score: 0.272
Data Source: BioPlex,STRINGDB
METAP1
Tchem
Family: Enzyme
Novelty: 0.01816253
p_int: 0.998742335
p_ni: 0.001257665
Data Source: BioPlex
NAA35
Tbio
Family: Enzyme
Novelty: 0.04980045
p_int: 0.998735179
p_ni: 0.001199629
p_wrong: 0.000065192
Score: 0.154
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  99.13

PubMed score by year
PubTator Score  34.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer