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Tclin
CD22
B-cell receptor CD22

Protein Summary
Description
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000085219
  • ENSP00000085219
  • ENSG00000012124
  • ENST00000341773
  • ENSP00000339349
  • ENST00000419549
  • ENSP00000403822
  • ENST00000536635
  • ENSP00000442279
  • ENST00000544992
  • ENSP00000441237
  • ENST00000594250
  • ENSP00000469984

Symbol
  • SIGLEC2
  • SIGLEC2
  • SIGLEC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cellular component
0.69
transcription factor
0.62
tissue
0.61
kinase perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1108.82   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 2035   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1108.82   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 2035   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
7
92.3
mean corpuscular hemoglobin concentration
1
1
1
73.5
red blood cell density measurement
1
1
1
53.7
lymphocyte count
1
1
1
47.7
erythrocyte count
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
92.3
mean corpuscular hemoglobin concentration
1
73.5
red blood cell density measurement
1
53.7
lymphocyte count
1
47.7
erythrocyte count
1
46.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD22 molecule
VGNC:2369
450167
Macaque
CD22 molecule
106994739
Mouse
MGI:88322
12483
Rat
RGD:1311610
308501
Dog
CD22 molecule
VGNC:38939
476485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD22 molecule
Macaque
CD22 molecule
Mouse
Rat
Dog
CD22 molecule
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20273-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
CD22 mediated BCR regulation
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
CD22 mediated BCR regulation
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (168)
1 – 10 of 168
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.939567217
p_ni:  0.060432783
Score:  0.226
Data Source:  BioPlex,STRINGDB
S100A7
Tbio
Novelty:  0.00434262
p_int:  0.846060521
p_ni:  0.153939479
Score:  0.345
Data Source:  BioPlex,STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.987
Data Source:  Reactome,STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.981
Data Source:  Reactome,STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.98
Data Source:  Reactome,STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.979
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.977
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.977
Data Source:  Reactome,STRINGDB
CD19
Tclin
Novelty:  0.0001816
Score:  0.96
Data Source:  STRINGDB
BCL6
Tchem
Family:  TF
Novelty:  0.00066258
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1108.82

PubMed score by year
PubTator Score  586.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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