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Tbio
POU3F2
POU domain, class 3, transcription factor 2

Protein Summary
Description
Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328345
  • ENSP00000329170
  • ENSG00000184486

Symbol
  • BRN2
  • OCT7
  • OTF7
  • BRN2
  • OCT7
  • OTF7
  • OTF-7
  • POUF3
  • brn-2
  • oct-7
  • N-Oct3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.85
molecular function
0.67
transcription factor binding site profile
0.66
gene perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.98   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.98   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
85.8
cognitive function measurement
3
2
3
85.5
intelligence
1
1
0
6.5
79
self reported educational attainment
2
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
85.8
cognitive function measurement
3
85.5
intelligence
0
6.5
79
self reported educational attainment
2
61.8
Pathways (18)
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
miRs in Muscle Cell Differentiation
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
MECP2 and Associated Rett Syndrome
miRs in Muscle Cell Differentiation
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (115)
1 – 10 of 115
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.895
Data Source: STRINGDB
MYT1L
Tbio
Family: TF
Novelty: 0.0174369
Score: 0.863
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.836
Data Source: STRINGDB
ARNT2
Tbio
Family: TF
Novelty: 0.01485424
Score: 0.824
Data Source: STRINGDB
SOX10
Tbio
Family: TF
Novelty: 0.00130552
Score: 0.804
Data Source: STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00094044
Score: 0.779
Data Source: STRINGDB
SOX11
Tbio
Family: TF
Novelty: 0.00516158
Score: 0.759
Data Source: STRINGDB
NES
Tbio
Novelty: 0.00035379
Score: 0.738
Data Source: STRINGDB
NPAS3
Tbio
Family: TF
Novelty: 0.02597048
Score: 0.733
Data Source: STRINGDB
SOX1
Tbio
Family: TF
Novelty: 0.0045679
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  148.98

PubMed score by year
PubTator Score  174.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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