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Tchem
CCNA2
Cyclin-A2

Protein Summary
Description
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274026
  • ENSP00000274026
  • ENSG00000145386
  • ENST00000618014
  • ENSP00000481380

Symbol
  • CCN1
  • CCNA
  • CCN1
  • CCNA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
drug
0.97
kinase perturbation
0.95
co-expressed gene
0.93
virus
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1867.89   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 731   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1867.89   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (609)
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  1
Score:  0.979
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999999999
p_ni:  1e-9
Score:  0.943
Data Source:  BioPlex,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.999999999
p_ni:  1e-9
Score:  0.931
Data Source:  BioPlex,STRINGDB
HELB
Tbio
Family:  Enzyme
Novelty:  0.02267221
p_int:  0.999999998
p_ni:  2e-9
Score:  0.364
Data Source:  BioPlex,STRINGDB
SCAPER
Tbio
Family:  Enzyme
Novelty:  0.10315854
p_int:  0.999999997
p_ni:  3e-9
Score:  0.637
Data Source:  BioPlex,STRINGDB
RBL1
Tbio
Novelty:  0.00228265
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
PKMYT1
Tchem
Family:  Kinase
Novelty:  0.03025516
p_int:  0.999999982
p_ni:  1.2e-8
p_wrong:  7e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.992
Data Source:  BioPlex,STRINGDB
Pathways (351)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

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Items per page:
1 – 5 of 55
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
CDK-mediated phosphorylation and removal of Cdc6
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
3
3
85.7
mean corpuscular hemoglobin concentration
2
2
2
85.2
1
1
1
84.3
mean reticulocyte volume
1
1
1
75.4
BMI-adjusted hip circumference
1
3
3
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
85.7
mean corpuscular hemoglobin concentration
2
85.2
1
84.3
mean reticulocyte volume
1
75.4
BMI-adjusted hip circumference
3
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin A2
VGNC:574
461467
Macaque
cyclin A2
707259
Mouse
MGI:108069
12428
Rat
RGD:621059
114494
Dog
cyclin A2
VGNC:38893
483845
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin A2
Macaque
cyclin A2
Mouse
Rat
Dog
cyclin A2
Publication Statistics
PubMed Score 1867.89
PubMed score by year
PubTator Score 1330.35
PubTator score by year
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Related Publications
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PMID
Year
Title