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Tchem
TPSB2
Tryptase beta-2

Protein Summary
Description
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000606293
  • ENSP00000482743
  • ENSG00000197253

Symbol
  • TPS2
  • TPS2
  • tryptaseB
  • tryptaseC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.69
hub protein
0.67
protein domain
0.58
cell line
0.55
small molecule perturbation
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.79   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.79   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL4468000
Rendered image for CHEMBL4468000
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
90.4
self reported educational attainment
1
1
1
73.3
neutrophil count
2
2
2
71.5
myeloid white cell count
1
1
1
70
leukocyte count
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
90.4
self reported educational attainment
1
73.3
neutrophil count
2
71.5
myeloid white cell count
1
70
leukocyte count
1
62.1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20231-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (29)
1 – 10 of 29
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.996523879
p_ni:  0.003476121
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.994681681
p_ni:  0.005318318
p_wrong:  1e-9
Data Source:  BioPlex
PRKD2
Tchem
Family:  Kinase
Novelty:  0.03143723
p_int:  0.974540457
p_ni:  0.025345187
p_wrong:  0.000114357
Data Source:  BioPlex
TUBA1A
Tchem
Novelty:  0.01030145
p_int:  0.924161315
p_ni:  0.075838685
Data Source:  BioPlex
TUBB4A
Tclin
Novelty:  0.00045092
p_int:  0.922143571
p_ni:  0.077856429
Data Source:  BioPlex
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.919485583
p_ni:  0.080514153
p_wrong:  2.64e-7
Data Source:  BioPlex
TUBB2A
Tclin
Novelty:  0.00902924
p_int:  0.855493166
p_ni:  0.144506834
Data Source:  BioPlex
ACOT9
Tbio
Family:  Enzyme
Novelty:  0.17405187
p_int:  0.837761088
p_ni:  0.162238893
p_wrong:  2e-8
Data Source:  BioPlex
XRCC3
Tbio
Novelty:  0.00266163
p_int:  0.834572249
p_ni:  0.165427739
p_wrong:  1.2e-8
Data Source:  BioPlex
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
p_int:  0.829596058
p_ni:  0.170403942
Score:  0.169
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  225.79

PubMed score by year
PubTator Score  20.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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