Tbio SPINK2 Serine protease inhibitor Kazal-type 2

Protein Summary

Description

Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin. This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• P20155
• Q6FGH2

Gene Name

• SPINK2

Ensembl ID

• ENST00000248701
• ENSP00000248701
• ENSG00000128040

Symbol

• SPGF29
• HUSI-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.75
cell type or tissue	0.61
histone modification site profile	0.61
small molecule perturbation	0.51
cell line	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.04   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.04   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0