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Tdark
SPINK2
Serine protease inhibitor Kazal-type 2

Protein Summary
Description
Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin. This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248701
  • ENSP00000248701
  • ENSG00000128040

Symbol
  • SPGF29
  • HUSI-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.75
cell type or tissue
0.61
histone modification site profile
0.61
small molecule perturbation
0.51
cell line
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.28   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.28   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
89.1
reticulocyte count
2
2
2
77.5
reticulocyte measurement
3
2
3
77
lymphocyte count
2
2
2
76.4
platelet count
3
2
3
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.1
reticulocyte count
2
77.5
reticulocyte measurement
3
77
lymphocyte count
2
76.4
platelet count
3
73.6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20155-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (60)
1 – 10 of 60
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
p_int:  0.999999659
p_ni:  3.4e-7
Data Source:  BioPlex
ATP5S
Tbio
Family:  Enzyme
Novelty:  0.15637839
p_int:  0.999981921
p_ni:  0.000016838
p_wrong:  0.000001241
Score:  0.202
Data Source:  BioPlex,STRINGDB
NUDT8
Tdark
Novelty:  0.76306116
p_int:  0.999709487
p_ni:  0.000289695
p_wrong:  8.18e-7
Score:  0.656
Data Source:  BioPlex,STRINGDB
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
p_int:  0.99905188
p_ni:  0.00094812
Data Source:  BioPlex
DCAF15
Tdark
Novelty:  0.13476661
p_int:  0.997711174
p_ni:  0.002279756
p_wrong:  0.000009069
Data Source:  BioPlex
CTTNBP2NL
Tbio
Novelty:  0.52774527
p_int:  0.997236221
p_ni:  0.002763779
Score:  0.179
Data Source:  BioPlex,STRINGDB
PRTFDC1
Tbio
Family:  Enzyme
Novelty:  0.13607881
p_int:  0.991941354
p_ni:  0.001610089
p_wrong:  0.006448557
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.991720755
p_ni:  0.008279245
Data Source:  BioPlex
PDP2
Tbio
Family:  Enzyme
Novelty:  0.0259516
p_int:  0.990132129
p_ni:  0.000877819
p_wrong:  0.008990052
Score:  0.165
Data Source:  BioPlex,STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.989303591
p_ni:  0.010696409
Data Source:  BioPlex
Publication Statistics
PubMed Score  16.28

PubMed score by year
PubTator Score  8.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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