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Tchem
KLK2
Kallikrein-2

Protein Summary
Description
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325321
  • ENSP00000313581
  • ENSG00000167751
  • ENST00000358049
  • ENSP00000350748
  • ENST00000391810
  • ENSP00000375686
  • ENST00000597439
  • ENSP00000471214

Symbol
  • hK2
  • hGK-1
  • KLK2A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.81
cell type or tissue
0.73
PubMedID
0.62
protein domain
0.58
virus perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.57   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.57   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (82)
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.919695626
p_ni:  0.07762684
p_wrong:  0.002677534
Score:  0.413
Data Source:  BioPlex,STRINGDB
APLP2
Tbio
Novelty:  0.0082936
p_int:  0.888497515
p_ni:  0.111502485
Score:  0.578
Data Source:  BioPlex,STRINGDB
GLG1
Tbio
Novelty:  0.01332149
p_int:  0.761599063
p_ni:  0.238400933
p_wrong:  4e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.986
Data Source:  STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.926
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.921
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.919
Data Source:  STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.917
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.915
Data Source:  STRINGDB
H2AFV
Tbio
Novelty:  0.03561635
Score:  0.913
Data Source:  STRINGDB
Pathways (14)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
8
6
7
39.1
99.8
9
7
2
1.2
99.3
blood protein measurement
2
2
2
92.6
kallikrein‐6 measurement
1
1
1
77.4
1
2
0
1.3
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
7
39.1
99.8
2
1.2
99.3
blood protein measurement
2
92.6
kallikrein‐6 measurement
1
77.4
0
1.3
74.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein-2
748637
Mouse
MGI:102850
16612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein-2
Mouse
Publication Statistics
PubMed Score 236.57
PubMed score by year
PubTator Score 138.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title