Protein Summary
Hydrolyzes a variety of proteins. This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
- ENST00000373025
- ENSP00000362116
- ENSG00000096088
- ENST00000425343
- ENSP00000405094
- PEPC
- PGII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
cell type or tissue | 0.64 | ||
protein domain | 0.58 | ||
cell line | 0.56 | ||
disease perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 540.5 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 399 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 540.5 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 399 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0