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Tchem
PGC
Gastricsin

Protein Summary
Description
Hydrolyzes a variety of proteins. This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373025
  • ENSP00000362116
  • ENSG00000096088
  • ENST00000425343
  • ENSP00000405094

Symbol
  • PEPC
  • PGII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
cell type or tissue
0.64
protein domain
0.58
cell line
0.56
disease perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.17   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.17   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
92.7
glomerular filtration rate
5
4
4
5.5
89.7
testosterone measurement
3
2
3
66.6
BMI-adjusted waist-hip ratio
2
1
2
66.3
BMI-adjusted hip circumference
2
2
2
64.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
92.7
glomerular filtration rate
4
5.5
89.7
testosterone measurement
3
66.6
BMI-adjusted waist-hip ratio
2
66.3
BMI-adjusted hip circumference
2
64.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progastricsin
VGNC:11195
107975138
Mouse
MGI:98909
109820
Rat
RGD:3943
24864
Dog
progastricsin [Source:HGNC Symbol;Acc:HGNC:8890]
Cow
progastricsin
VGNC:32785
514502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progastricsin
Mouse
Rat
Dog
progastricsin [Source:HGNC Symbol;Acc:HGNC:8890]
Cow
progastricsin
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20142-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
VPS18
Tbio
Novelty:  0.00726539
Score:  0.75
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.739
Data Source:  STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
Score:  0.729
Data Source:  STRINGDB
PGD
Tchem
Family:  Enzyme
Novelty:  0.00576529
Score:  0.718
Data Source:  STRINGDB
UCP1
Tbio
Novelty:  0.00055954
Score:  0.673
Data Source:  STRINGDB
ME3
Tbio
Novelty:  0.00332825
Score:  0.67
Data Source:  STRINGDB
F13B
Tbio
Novelty:  0.00562478
Score:  0.649
Data Source:  STRINGDB
MPG
Tchem
Family:  Enzyme
Novelty:  0.00373538
Score:  0.645
Data Source:  STRINGDB
CTSA
Tchem
Family:  Enzyme
Novelty:  0.00170931
Score:  0.642
Data Source:  STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
Score:  0.638
Data Source:  STRINGDB
Publication Statistics
PubMed Score  482.17

PubMed score by year
PubTator Score  460.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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