CD33
Myeloid cell surface antigen CD33
Protein Summary
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosph ...more
- ENST00000262262
- ENSP00000262262
- ENSG00000105383
- ENST00000391796
- ENSP00000375673
- ENST00000421133
- ENSP00000410126
- SIGLEC3
- p67
- SIGLEC3
- SIGLEC-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
tissue sample | 0.71 | ||
cell line | 0.63 | ||
hub protein | 0.63 | ||
cellular component | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1247.5 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 2272 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1247.5 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 2272 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (284)
CALM3
Novelty: 0.00461552
p_int: 0.956380518
p_ni: 0.043619482
Score: 0.379
Data Source: BioPlex,STRINGDB
SLC39A11
Family: Transporter
Novelty: 0.09770302
p_int: 0.913567752
p_ni: 0.086432248
Score: 0.196
Data Source: BioPlex,STRINGDB
COMMD3
Novelty: 0.07399068
p_int: 0.859400132
p_ni: 0.140599814
p_wrong: 5.4e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 2 | 2 | 85.4 | |||||
leukocyte count | 2 | 2 | 2 | 84.4 | |||||
myeloid white cell count | 1 | 1 | 1 | 83.1 | |||||
platelet crit | 2 | 2 | 2 | 82.7 | |||||
C-reactive protein measurement | 1 | 2 | 2 | 74.7 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 85.4 | |||||
leukocyte count | 2 | 84.4 | |||||
myeloid white cell count | 1 | 83.1 | |||||
platelet crit | 2 | 82.7 | |||||
C-reactive protein measurement | 2 | 74.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD33 molecule | VGNC:2366 | 456242 | |||||
Macaque | CD33 molecule | 719855 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD33 molecule | |||||
Macaque | CD33 molecule | |||||
Publication Statistics
PubMed Score 1247.50
PubMed score by year
PubTator Score 1034.73
PubTator score by year
Related Publications
Text Mined References (90)
GeneRif Annotations (65)
Items per page:
0 of 0
PMID | Year | Title |
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