Tclin CD33 Myeloid cell surface antigen CD33

Protein Summary

Description

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).

Uniprot Accession IDs

• P20138
• B4E3P8
• C9JEN7
• F8WAL2
• Q8TD24

Gene Name

• CD33

Ensembl ID

• ENST00000262262
• ENSP00000262262
• ENSG00000105383
• ENST00000391796
• ENSP00000375673
• ENST00000421133
• ENSP00000410126

Symbol

• SIGLEC3
• p67
• SIGLEC3
• SIGLEC-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.71
cell line	0.63
hub protein	0.63
cellular component	0.59

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myelin Protein / Myeloid Cell Surface Antigen Cd33

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Myeloid Cell Surface Antigen Cd33

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Myeloid Cell Surface Antigen Cd33

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Myeloid Cell Surface Antigen Cd33

Protein / Cell Adhesion Molecule / Immunoglobulin Superfamily Cell Adhesion Molecule / Myeloid Cell Surface Antigen Cd33

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Myeloid Cell Surface Antigen Cd33

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1463.39   (req: < 5)

Gene RIFs: 98   (req: <= 3)

Antibodies: 2272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1463.39   (req: >= 5)

Gene RIFs: 98   (req: > 3)

Antibodies: 2272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1