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Tclin
CD33
Myeloid cell surface antigen CD33

Protein Classes
Protein Summary
Description
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262262
  • ENSP00000262262
  • ENSG00000105383
  • ENST00000391796
  • ENSP00000375673
  • ENST00000421133
  • ENSP00000410126

Symbol
  • SIGLEC3
  • p67
  • SIGLEC3
  • SIGLEC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.71
cell line
0.63
hub protein
0.63
cellular component
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1220.55   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 2272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1220.55   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 2272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
82.2
lymphocyte count
1
1
1
80.1
neutrophil count
2
1
2
74.7
basophil count
2
1
2
64.5
leukocyte count
1
1
1
50.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
82.2
lymphocyte count
1
80.1
neutrophil count
2
74.7
basophil count
2
64.5
leukocyte count
1
50.1
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD33 molecule
VGNC:2366
456242
Macaque
CD33 molecule
719855
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD33 molecule
Macaque
CD33 molecule
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20138-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (284)
1 – 10 of 284
CALM3
Tclin
Novelty: 0.00461552
p_int: 0.956380518
p_ni: 0.043619482
Score: 0.379
Data Source: BioPlex,STRINGDB
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.939725959
p_ni: 0.060274041
Data Source: BioPlex
SLC39A11
Tbio
Family: Transporter
Novelty: 0.09770302
p_int: 0.913567752
p_ni: 0.086432248
Score: 0.196
Data Source: BioPlex,STRINGDB
COMMD3
Tbio
Novelty: 0.07399068
p_int: 0.859400132
p_ni: 0.140599814
p_wrong: 5.4e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.981
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.969
Data Source: STRINGDB
CEACAM8
Tbio
Novelty: 0.00370138
Score: 0.966
Data Source: STRINGDB
CLEC12A
Tbio
Novelty: 0.01478908
Score: 0.959
Data Source: STRINGDB
LAIR1
Tbio
Novelty: 0.0133817
Score: 0.952
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  1220.55

PubMed score by year
PubTator Score  1034.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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