Tclin CD33 Myeloid cell surface antigen CD33

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myelin Protein / Myeloid Cell Surface Antigen Cd33

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Myeloid Cell Surface Antigen Cd33

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Myeloid Cell Surface Antigen Cd33

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Myeloid Cell Surface Antigen Cd33

Protein / Cell Adhesion Molecule / Immunoglobulin Superfamily Cell Adhesion Molecule / Myeloid Cell Surface Antigen Cd33

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Myeloid Cell Surface Antigen Cd33

Protein Summary

Description

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).

Uniprot Accession IDs

• P20138
• B4E3P8
• C9JEN7
• F8WAL2
• Q8TD24

Gene Name

• CD33

Ensembl ID

• ENST00000262262
• ENSP00000262262
• ENSG00000105383
• ENST00000391796
• ENSP00000375673
• ENST00000421133
• ENSP00000410126

Symbol

• SIGLEC3
• p67
• SIGLEC3
• SIGLEC-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.71
cell line	0.63
hub protein	0.63
cellular component	0.59

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1220.55   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 2272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1220.55   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 2272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

gemtuzumab ozogamicin

CD33Tclin

ANTIBODY BINDING :

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	1	1	1		82.2
lymphocyte count	EFO_0004587	1	1	1		80.1
neutrophil count	EFO_0004833	2	1	2		74.7
basophil count	EFO_0005090	2	1	2		64.5
leukocyte count	EFO_0004308	1	1	1		50.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	1		82.2
lymphocyte count	EFO_0004587	1		80.1
neutrophil count	EFO_0004833	2		74.7
basophil count	EFO_0005090	2		64.5
leukocyte count	EFO_0004308	1		50.1

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Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD33 molecule	VGNC:2366	456242
Macaque	CD33 molecule		719855

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD33 molecule
Macaque	CD33 molecule

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20138-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (6)

Reactome (5)

KEGG (1)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Immune System	2246 targets	R-HSA-168256
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (18)

Functions (3)

Components (8)

Processes (7)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein phosphatase binding	Inferred from Physical Interaction (IPI)	UniProtKB
signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
carbohydrate binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (284)

Explore Interacting Targets

1 – 10 of 284

• See Interactions on String-DB

CALM3

Tclin

Novelty: 0.00461552

p_int: 0.956380518

p_ni: 0.043619482

Score: 0.379

Data Source: BioPlex,STRINGDB

PEX19

Tbio

Novelty: 0.00605342

p_int: 0.939725959

p_ni: 0.060274041

Data Source: BioPlex

SLC39A11

Tbio

Family: Transporter

Novelty: 0.09770302

p_int: 0.913567752

p_ni: 0.086432248

Score: 0.196

Data Source: BioPlex,STRINGDB

COMMD3

Tbio

Novelty: 0.07399068

p_int: 0.859400132

p_ni: 0.140599814

p_wrong: 5.4e-8

Score: 0.158

Data Source: BioPlex,STRINGDB

ITGAM

Tbio

Novelty: 0.00017521

Score: 0.981

Data Source: STRINGDB

ITGAX

Tbio

Novelty: 0.00040471

Score: 0.969

Data Source: STRINGDB

CEACAM8

Tbio

Novelty: 0.00370138

Score: 0.966

Data Source: STRINGDB

CLEC12A

Tbio

Novelty: 0.01478908

Score: 0.959

Data Source: STRINGDB

LAIR1

Tbio

Novelty: 0.0133817

Score: 0.952

Data Source: STRINGDB

ITGAL

Tclin

Novelty: 0.00099016

Score: 0.951

Data Source: STRINGDB

Publication Statistics

PubMed Score  1220.55

PubMed score by year

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PubTator Score  1034.73

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Lectin
Membrane

GWAS Trait Find Similar Targets

basophil count
leukocyte count
lymphocyte count
myeloid white cell count
neutrophil count
platelet crit
reticulocyte measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype