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Tbio
ANXA7
Annexin A7

Protein Summary
Description
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372919
  • ENSP00000362010
  • ENSG00000138279
  • ENST00000372921
  • ENSP00000362012

Symbol
  • ANX7
  • SNX
  • SNX
  • ANX7
  • SYNEXIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
transcription factor perturbation
0.98
histone modification site profile
0.91
cellular component
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.79   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.79   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
annexin A7
VGNC:3806
737825
Macaque
annexin A7
707166
Mouse
MGI:88031
11750
Rat
RGD:621173
155423
Dog
annexin A7
VGNC:37944
479246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
annexin A7
Macaque
annexin A7
Mouse
Rat
Dog
annexin A7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P20073-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (104)
1 – 10 of 104
MOB1A
Tbio
Family: Enzyme
Novelty: 0.01430129
p_int: 0.991560433
p_ni: 0.008438426
p_wrong: 0.000001141
Score: 0.687
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
PARK7
Tbio
Family: Enzyme
Novelty: 0.00104651
Score: 0.863
Data Source: STRINGDB
SRI
Tbio
Novelty: 0.00237519
Score: 0.821
Data Source: STRINGDB
VPS26A
Tbio
Novelty: 0.01804654
Score: 0.809
Data Source: STRINGDB
SERPINE2
Tbio
Novelty: 0.00246375
Score: 0.793
Data Source: STRINGDB
C11orf54
Tbio
Family: Enzyme
Novelty: 0.5374767
Score: 0.789
Data Source: STRINGDB
VPS35
Tbio
Novelty: 0.00729892
Score: 0.768
Data Source: STRINGDB
VPS29
Tbio
Novelty: 0.01335106
Score: 0.764
Data Source: STRINGDB
PDCD6
Tbio
Novelty: 0.0139857
Score: 0.763
Data Source: STRINGDB
Publication Statistics
PubMed Score  297.79

PubMed score by year
PubTator Score  117.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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