Protein Summary
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- ENST00000215838
- ENSP00000215838
- ENSG00000185339
- ENST00000407817
- ENSP00000384914
- TC2
- II
- TC
- TC2
- TC-2
- TCII
- TC II
- D22S676
- D22S750
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
disease perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.78 | ||
disease | 0.71 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 483.66 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 212 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 483.66 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 212 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
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1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Nephroblastoma | 1 | 1 | 0 | 2 | 72 | ||||
Moyamoya disease | 1 | 1 | 0 | 1.9 | 47.7 | ||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Nephroblastoma | 0 | 2 | 72 | ||||
Moyamoya disease | 0 | 1.9 | 47.7 | ||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transcobalamin 2 | VGNC:6160 | 470178 | |||||
Macaque | transcobalamin 2 | 716085 | ||||||
Mouse | MGI:98534 | 21452 | ||||||
Rat | RGD:620681 | 64365 | ||||||
Dog | transcobalamin 2 | VGNC:47205 | 486355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transcobalamin 2 | |||||
Macaque | transcobalamin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transcobalamin 2 | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (14)
Reactome (10)
KEGG (1)
WikiPathways (3)
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Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective CD320 causes methylmalonic aciduria | ||||
Reactome | Defective TCN2 causes hereditary megaloblastic anemia | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective CD320 causes methylmalonic aciduria | ||||
Defective TCN2 causes hereditary megaloblastic anemia | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (61)
1 – 10 of 61
CD320
Novelty: 0.01978884
Score: 0.994
Data Source: Reactome,STRINGDB
MTR
Family: Enzyme
Novelty: 0.0006987
Score: 0.806
Data Source: STRINGDB
MTRR
Family: Enzyme
Novelty: 0.00231914
Score: 0.79
Data Source: STRINGDB
MTHFR
Family: Enzyme
Novelty: 0.00018162
Score: 0.739
Data Source: STRINGDB
SLC19A1
Family: Transporter
Novelty: 0.00536763
Score: 0.708
Data Source: STRINGDB
BHMT
Family: Enzyme
Novelty: 0.00453508
Score: 0.69
Data Source: STRINGDB
MTHFD1
Family: Enzyme
Novelty: 0.0071938
Score: 0.675
Data Source: STRINGDB
CUBN
Novelty: 0.00441944
Score: 0.671
Data Source: STRINGDB
BHMT2
Family: Enzyme
Novelty: 0.07713739
Score: 0.663
Data Source: STRINGDB
MMADHC
Novelty: 0.02299238
Score: 0.653
Data Source: STRINGDB
Publication Statistics
PubMed Score 483.66
PubMed score by year
PubTator Score 388.61
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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