Protein Summary
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- ENST00000215838
- ENSP00000215838
- ENSG00000185339
- ENST00000407817
- ENSP00000384914
- TC2
- II
- TC
- TC2
- TC-2
- TCII
- TC II
- D22S676
- D22S750
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
disease perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.78 | ||
disease | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 487.35 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 212 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 487.35 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 212 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (61)
Nearest Tclin Targets
Pathways (14)
Reactome (10)
KEGG (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective CD320 causes methylmalonic aciduria | ||||
Reactome | Defective TCN2 causes hereditary megaloblastic anemia | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective CD320 causes methylmalonic aciduria | ||||
Defective TCN2 causes hereditary megaloblastic anemia | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 2 | 2 | 72.9 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 61.4 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 61 | |||||
1 | 1 | 0 | 2 | 52.7 | |||||
sporadic Creutzfeld Jacob disease | 1 | 1 | 0 | 1.1 | 42.3 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 2 | 72.9 | |||||
high density lipoprotein cholesterol measurement | 1 | 61.4 | |||||
apolipoprotein A 1 measurement | 1 | 61 | |||||
0 | 2 | 52.7 | |||||
sporadic Creutzfeld Jacob disease | 0 | 1.1 | 42.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transcobalamin 2 | VGNC:6160 | 470178 | |||||
Macaque | transcobalamin 2 | 716085 | ||||||
Mouse | MGI:98534 | 21452 | ||||||
Rat | RGD:620681 | 64365 | ||||||
Dog | transcobalamin 2 | VGNC:47205 | 486355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transcobalamin 2 | |||||
Macaque | transcobalamin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transcobalamin 2 | |||||
Publication Statistics
PubMed Score 487.35
PubMed score by year
PubTator Score 388.61
PubTator score by year
Related Publications
Text Mined References (124)
GeneRif Annotations (63)
Items per page:
0 of 0
PMID | Year | Title |
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