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Tbio
EIF2S2
Eukaryotic translation initiation factor 2 subunit 2

Protein Summary
Description
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374980
  • ENSP00000364119
  • ENSG00000125977

Symbol
  • EIF2B
  • EIF2
  • EIF2B
  • PPP1R67
  • EIF2beta
  • eIF-2-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
transcription factor perturbation
0.96
kinase perturbation
0.93
disease perturbation
0.87
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.22   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.22   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
91.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 subunit beta
VGNC:9845
458188
Macaque
eukaryotic translation initiation factor 2 subunit beta
708593
Mouse
MGI:1914454
67204
Rat
RGD:735192
296302
Dog
eukaryotic translation initiation factor 2 subunit beta
VGNC:40267
477197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 subunit beta
Macaque
eukaryotic translation initiation factor 2 subunit beta
Mouse
Rat
Dog
eukaryotic translation initiation factor 2 subunit beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P20042-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of the ternary complex, and subsequently, the 43S complex
Protein-Protein Interactions (299)
1 – 10 of 299
PRMT7
Tchem
Family: Epigenetic
Novelty: 0.02310897
p_int: 0.999999744
p_ni: 2.7e-8
p_wrong: 2.28e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
EIF2S1
Tbio
Novelty: 0.00076124
p_int: 0.99980766
p_ni: 0.00019234
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDC123
Tbio
Novelty: 0.05599841
p_int: 0.999566892
p_ni: 0.000433106
p_wrong: 3e-9
Score: 0.643
Data Source: BioPlex,STRINGDB
EIF2S3
Tbio
Novelty: 0.02055484
p_int: 0.981818933
p_ni: 0.018181067
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
Score: 0.997
Data Source: STRINGDB
EIF2B3
Tbio
Novelty: 0.04963646
Score: 0.995
Data Source: STRINGDB
EIF1AX
Tbio
Novelty: 0.01945373
Score: 0.994
Data Source: Reactome,STRINGDB
EIF1
Tbio
Novelty: 0.00590381
Score: 0.994
Data Source: STRINGDB
EIF3I
Tbio
Novelty: 0.04398155
Score: 0.993
Data Source: STRINGDB
EIF3B
Tbio
Novelty: 0.00889042
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.22

PubMed score by year
PubTator Score  308.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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