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Tbio
CR2
Complement receptor type 2

Protein Summary
Description
Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). (Microbial infection) Acts as a receptor for Epstein-Barr virus. This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367057
  • ENSP00000356024
  • ENSG00000117322
  • ENST00000367058
  • ENSP00000356025

Symbol
  • C3DR
  • CR
  • C3DR
  • CD21
  • CVID7
  • SLEB9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
biological term
0.81
disease
0.63
transcription factor
0.63
histone modification site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1107.67   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 1245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1107.67   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 1245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
0
1.2
87.6
family history of Alzheimer’s disease
2
2
0
1.1
81.6
late-onset Alzheimers disease
1
1
0
1.2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
87.6
family history of Alzheimer’s disease
0
1.1
81.6
late-onset Alzheimers disease
0
1.2
46.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C3d receptor 2
VGNC:8246
457690
Macaque
complement C3d receptor 2
714202
Mouse
MGI:88489
12902
Rat
RGD:1310065
289395
Cow
complement C3d receptor 2
VGNC:27684
407126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C3d receptor 2
Macaque
complement C3d receptor 2
Mouse
Rat
Cow
complement C3d receptor 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20023-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (127)
1 – 10 of 127
CD19
Tclin
Novelty:  0.0001816
Score:  0.996
Data Source:  Reactome,STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.994
Data Source:  Reactome,STRINGDB
CD81
Tchem
Novelty:  0.00111328
Score:  0.975
Data Source:  Reactome,STRINGDB
CD5
Tbio
Novelty:  0.00032883
Score:  0.874
Data Source:  STRINGDB
IFNA17
Tbio
Novelty:  0.0030696
Score:  0.852
Data Source:  STRINGDB
IFNA21
Tbio
Novelty:  0.00581034
Score:  0.852
Data Source:  STRINGDB
IFNA2
Tbio
Novelty:  0.00032935
Score:  0.851
Data Source:  STRINGDB
SPN
Tbio
Novelty:  0.00121061
Score:  0.808
Data Source:  STRINGDB
TNFSF13B
Tclin
Novelty:  0.00069885
Score:  0.795
Data Source:  STRINGDB
CD27
Tbio
Novelty:  0.00090508
Score:  0.791
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1107.67

PubMed score by year
PubTator Score  1045.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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