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Tbio
ATP2B1
Plasma membrane calcium-transporting ATPase 1

Protein Summary
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively splic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261173
  • ENSP00000261173
  • ENSG00000070961
  • ENST00000359142
  • ENSP00000352054
  • ENST00000428670
  • ENSP00000392043

Symbol
  • PMCA1
  • PMCA1
  • PMCA1kb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
transcription factor perturbation
0.88
interacting protein
0.72
microRNA
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.77   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.77   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
5
4
1.1
96.1
diastolic blood pressure
8
8
15
94.8
3
3
3
89.8
mean arterial pressure
3
3
3
87.7
systolic blood pressure
2
2
2
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
96.1
diastolic blood pressure
15
94.8
3
89.8
mean arterial pressure
3
87.7
systolic blood pressure
2
87.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase plasma membrane Ca2+ transporting 1
VGNC:8343
452116
Macaque
ATPase plasma membrane Ca2+ transporting 1
709102
Mouse
MGI:104653
67972
Rat
RGD:621303
29598
Dog
ATPase plasma membrane Ca2+ transporting 1
VGNC:38256
403480
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase plasma membrane Ca2+ transporting 1
Macaque
ATPase plasma membrane Ca2+ transporting 1
Mouse
Rat
Dog
ATPase plasma membrane Ca2+ transporting 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20020-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO-UCL
Inferred from Direct Assay (IDA)
SynGO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (117)
1 – 10 of 117
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
p_int: 0.974843796
p_ni: 0.025156204
Score: 0.52
Data Source: BioPlex,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.877
Data Source: STRINGDB
PRKG2
Tchem
Family: Kinase
Novelty: 0.0138455
Score: 0.818
Data Source: STRINGDB
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
Score: 0.809
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.809
Data Source: STRINGDB
UBE3B
Tbio
Family: Enzyme
Novelty: 0.06274049
Score: 0.809
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.792
Data Source: STRINGDB
TRPV6
Tchem
Family: IC
Novelty: 0.00383629
Score: 0.782
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.755
Data Source: STRINGDB
S100G
Tbio
Novelty: 0.00314874
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score  142.77

PubMed score by year
PubTator Score  64.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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