Protein Classes
Protein Summary
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
- ENST00000252029
- ENSP00000252029
- ENSG00000025708
- ENST00000395678
- ENSP00000379036
- ENST00000395680
- ENSP00000379037
- ENST00000395681
- ENSP00000379038
- ECGF1
- TP
- ECGF
- ECGF1
- MNGIE
- MEDPS1
- MTDPS1
- PDECGF
- hPD-ECGF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.85 | ||
protein domain | 0.85 | ||
disease | 0.71 | ||
tissue sample | 0.65 | ||
biological process | 0.64 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 666.73 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 755 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 666.73 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 755 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (21)
1 – 10 of 21
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (22)
Reactome (6)
KEGG (4)
PathwayCommons (6)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Nucleotide salvage | ||||
Pyrimidine catabolism | ||||
Gene Ontology Terms (18)
Functions (6)
Components (1)
Processes (11)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (102)
1 – 10 of 102
KLHL11
Novelty: 0.39728266
p_int: 0.99993833
p_ni: 0.000061669
p_wrong: 1e-9
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 3.88235294
p_int: 0.999897598
p_ni: 0.000102402
Score: 0.205
Data Source: BioPlex,STRINGDB
TEFM
Novelty: 0.13341034
p_int: 0.999870408
p_ni: 0.000129592
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.05099873
p_int: 0.999848319
p_ni: 0.000151681
Data Source: BioPlex
GPATCH2L
Novelty: 4
p_int: 0.999818257
p_ni: 0.000181743
Score: 0.173
Data Source: BioPlex,STRINGDB
TBC1D22B
Novelty: 6
p_int: 0.999707575
p_ni: 0.000292425
Data Source: BioPlex
PDE4DIP
Novelty: 0.04181178
p_int: 0.999193331
p_ni: 0.000806669
Data Source: BioPlex
YJU2
Novelty: 0.75
p_int: 0.997996622
p_ni: 0.002003378
Data Source: BioPlex
SUSD3
Novelty: 1
p_int: 0.994229778
p_ni: 0.005761562
p_wrong: 0.00000866
Score: 0.18
Data Source: BioPlex,STRINGDB
SINHCAF
Novelty: 0.25139665
p_int: 0.993710714
p_ni: 0.006288702
p_wrong: 5.84e-7
Data Source: BioPlex
Publication Statistics
PubMed Score 666.73
PubMed score by year
PubTator Score 538.48
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQ
1-70
IGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKV
70-140
PMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDS
140-210
LPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRC
210-280
VGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQ
280-350
GVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
350-420
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
420-482
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
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