Tclin TYMP Thymidine phosphorylase

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Thymidine Phosphorylase

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Thymidine Phosphorylase

Protein Summary

Description

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P19971
• A8MW15
• H9KVA0
• Q13390
• Q8WVB7
• TP

Gene Name

• TYMP

Ensembl ID

• ENST00000252029
• ENSP00000252029
• ENSG00000025708
• ENST00000395678
• ENSP00000379036
• ENST00000395680
• ENSP00000379037
• ENST00000395681
• ENSP00000379038

Symbol

• ECGF1
• TP
• ECGF
• ECGF1
• MNGIE
• MEDPS1
• MTDPS1
• PDECGF
• hPD-ECGF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.85
protein domain	0.85
disease	0.71
tissue sample	0.65
biological process	0.64

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.39   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 755   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.39   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 755   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

tipiracil

TYMPTclin Enzyme

INHIBITOR IC50 : 7.69896984

Active Ligands (26)

Explore Active Ligands

1 – 10 of 26

CHEMBL87371

TYMPTclin Enzyme

Ki : 6.11

5-bromo-6-[(2-aminoimidazol-1-yl)methyl]uracil hydrochloride

TYMPTclin Enzyme

IC50 : 8.72

5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil

TYMPTclin Enzyme

Ki : 7.77

CHEMBL4129617

TYMPTclin Enzyme

IC50 : 7.7

CHEMBL66531,CHEMBL193667

TYMPTclin Enzyme

IC50 : 7.68

6-amino-5-bromouracil

TYMPTclin Enzyme

IC50 : 7.46

CHEMBL194335,CHEMBL303346

TYMPTclin Enzyme

IC50 : 7

CHEMBL4293861

TYMPTclin Enzyme

IC50 : 6.92

CHEMBL4455140

TYMPTclin Enzyme

IC50 : 6.92

CHEMBL234998

TYMPTclin Enzyme

Ki : 6.54

GWAS Traits (23)

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1 – 5 of 23

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	5	7	8		99
mean reticulocyte volume	EFO_0010701	1	4	4		97.6
red blood cell distribution width	EFO_0005192	4	4	4		95.6
mean corpuscular hemoglobin	EFO_0004527	3	3	3		94.6
mean corpuscular hemoglobin concentration	EFO_0004528	2	2	2		91.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	8		99
mean reticulocyte volume	EFO_0010701	4		97.6
red blood cell distribution width	EFO_0005192	4		95.6
mean corpuscular hemoglobin	EFO_0004527	3		94.6
mean corpuscular hemoglobin concentration	EFO_0004528	2		91.5

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thymidine phosphorylase	VGNC:5982	458941
Macaque	thymidine phosphorylase		716161
Mouse	thymidine phosphorylase	MGI:1920212	72962
Rat	thymidine phosphorylase	RGD:1305756	315219
Horse	thymidine phosphorylase	VGNC:24688	100146854

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thymidine phosphorylase
Macaque	thymidine phosphorylase
Mouse	thymidine phosphorylase
Rat	thymidine phosphorylase
Horse	thymidine phosphorylase

Protein Structure (4 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19971-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (22)

Reactome (6)

KEGG (4)

PathwayCommons (6)

UniProt (1)

WikiPathways (5)

Metabolism (R-HSA-1430728)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869
Reactome	Nucleobase catabolism	36 targets	R-HSA-8956319
Reactome	Nucleotide salvage	23 targets	R-HSA-8956321
Reactome	Pyrimidine catabolism	12 targets	R-HSA-73621

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869
Nucleobase catabolism	36 targets	R-HSA-8956319
Nucleotide salvage	23 targets	R-HSA-8956321
Pyrimidine catabolism	12 targets	R-HSA-73621

Gene Ontology Terms (18)

Functions (6)

Components (1)

Processes (11)

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1 – 6 of 6

GO Term	Evidence	Assigned by
transferase activity, transferring pentosyl groups	Inferred from Experiment (EXP)	Reactome
protein homodimerization activity	Inferred from Direct Assay (IDA)	CAFA
thymidine phosphorylase activity	Inferred from Direct Assay (IDA)	CAFA
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
phosphorylase activity	Inferred from Electronic Annotation (IEA)	InterPro
pyrimidine-nucleoside phosphorylase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

• See Interactions on String-DB

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.99993833

p_ni:  0.000061669

p_wrong:  1e-9

Data Source:  BioPlex

CDK15

Tchem

Family:  Kinase

Novelty:  0.3870338

p_int:  0.999897598

p_ni:  0.000102402

Score:  0.205

Data Source:  BioPlex,STRINGDB

TEFM

Tbio

Novelty:  0.10836617

p_int:  0.999870408

p_ni:  0.000129592

Data Source:  BioPlex

DDX19B

Tbio

Family:  Enzyme

Novelty:  0.0504568

p_int:  0.999848319

p_ni:  0.000151681

Data Source:  BioPlex

GPATCH2L

Tdark

Novelty:  1.68490464

p_int:  0.999818257

p_ni:  0.000181743

Score:  0.173

Data Source:  BioPlex,STRINGDB

TBC1D22B

Tbio

Novelty:  0.49852962

p_int:  0.999707575

p_ni:  0.000292425

Data Source:  BioPlex

PDE4DIP

Tbio

Novelty:  0.03414104

p_int:  0.999193331

p_ni:  0.000806669

Data Source:  BioPlex

YJU2

Tdark

Novelty:  0.75647391

p_int:  0.997996622

p_ni:  0.002003378

Data Source:  BioPlex

SUSD3

Tdark

Novelty:  0.43699506

p_int:  0.994229778

p_ni:  0.005761562

p_wrong:  0.00000866

Score:  0.18

Data Source:  BioPlex,STRINGDB

SINHCAF

Tdark

Novelty:  0.18692832

p_int:  0.993710714

p_ni:  0.006288702

p_wrong:  5.84e-7

Data Source:  BioPlex

Publication Statistics

PubMed Score  616.39

PubMed score by year

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PubTator Score  538.48

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Angiogenesis
Chemotaxis
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disease mutation
Glycosyltransferase

GWAS Trait Find Similar Targets

No Header	No Header
age-related hearing impairment
blood metabolite measurement
chronic lymphocytic leukemia
diffuse large B-cell lymphoma
erythrocyte count
erythrocyte measurement
forced expiratory volume
granulocyte percentage of myeloid white cells
heel bone mineral density
hemoglobin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype