Protein Classes
Protein Summary
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
- ENST00000252029
- ENSP00000252029
- ENSG00000025708
- ENST00000395678
- ENSP00000379036
- ENST00000395680
- ENSP00000379037
- ENST00000395681
- ENSP00000379038
- ECGF1
- TP
- ECGF
- ECGF1
- MNGIE
- MEDPS1
- MTDPS1
- PDECGF
- hPD-ECGF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.85 | ||
protein domain | 0.85 | ||
disease | 0.71 | ||
tissue sample | 0.65 | ||
biological process | 0.64 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 609.26 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 755 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 609.26 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 755 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (21)
1 – 10 of 21
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 2 | 2 | 89.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 82.4 | |||||
mean corpuscular hemoglobin | 2 | 2 | 2 | 82 | |||||
red blood cell distribution width | 1 | 1 | 1 | 47.7 | |||||
hemoglobin measurement | 1 | 1 | 1 | 14.7 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 89.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 82.4 | |||||
mean corpuscular hemoglobin | 2 | 82 | |||||
red blood cell distribution width | 1 | 47.7 | |||||
hemoglobin measurement | 1 | 14.7 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thymidine phosphorylase | VGNC:5982 | 458941 | |||||
Macaque | thymidine phosphorylase | 716161 | ||||||
Mouse | MGI:1920212 | 72962 | ||||||
Rat | RGD:1305756 | 315219 | ||||||
Horse | thymidine phosphorylase | VGNC:24688 | 100146854 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thymidine phosphorylase | |||||
Macaque | thymidine phosphorylase | |||||
Mouse | ||||||
Rat | ||||||
Horse | thymidine phosphorylase | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (22)
Reactome (6)
KEGG (4)
PathwayCommons (6)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Nucleotide salvage | ||||
Pyrimidine catabolism | ||||
Gene Ontology Terms (18)
Functions (6)
Components (1)
Processes (11)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (102)
1 – 10 of 102
KLHL11
Novelty: 0.1537041
p_int: 0.99993833
p_ni: 0.000061669
p_wrong: 1e-9
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.999897598
p_ni: 0.000102402
Score: 0.205
Data Source: BioPlex,STRINGDB
TEFM
Novelty: 0.10836617
p_int: 0.999870408
p_ni: 0.000129592
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999848319
p_ni: 0.000151681
Data Source: BioPlex
GPATCH2L
Novelty: 1.68490464
p_int: 0.999818257
p_ni: 0.000181743
Score: 0.173
Data Source: BioPlex,STRINGDB
TBC1D22B
Novelty: 0.49852962
p_int: 0.999707575
p_ni: 0.000292425
Data Source: BioPlex
PDE4DIP
Novelty: 0.03414104
p_int: 0.999193331
p_ni: 0.000806669
Data Source: BioPlex
YJU2
Novelty: 0.75647391
p_int: 0.997996622
p_ni: 0.002003378
Data Source: BioPlex
SUSD3
Novelty: 0.43699506
p_int: 0.994229778
p_ni: 0.005761562
p_wrong: 0.00000866
Score: 0.18
Data Source: BioPlex,STRINGDB
SINHCAF
Novelty: 0.18692832
p_int: 0.993710714
p_ni: 0.006288702
p_wrong: 5.84e-7
Data Source: BioPlex
Publication Statistics
PubMed Score 609.26
PubMed score by year
PubTator Score 538.48
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait