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Tbio
PI3
Elafin

Protein Summary
Description
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243924
  • ENSP00000243924
  • ENSG00000124102

Symbol
  • WAP3
  • WFDC14
  • ESI
  • WAP3
  • SKALP
  • WFDC14
  • cementoin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
tissue sample
0.68
biological term
0.67
virus perturbation
0.64
tissue
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.82   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.82   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidase inhibitor 3
VGNC:6240
458276
Dog
peptidase inhibitor 3
VGNC:44516
477241
Horse
peptidase inhibitor 3
VGNC:21408
100056125
Cow
trappin 5
407163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidase inhibitor 3
Dog
peptidase inhibitor 3
Horse
peptidase inhibitor 3
Cow
trappin 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19957-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Developmental Biology
Formation of the cornified envelope
Immune System
Innate Immune System
Protein-Protein Interactions (297)
1 – 10 of 297
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.963
Data Source: STRINGDB
CSTA
Tbio
Novelty: 0.00453121
Score: 0.947
Data Source: STRINGDB
LOR
Tbio
Novelty: 0.0033781
Score: 0.942
Data Source: STRINGDB
IVL
Tbio
Novelty: 0.00147892
Score: 0.939
Data Source: STRINGDB
EVPL
Tbio
Novelty: 0.00274279
Score: 0.936
Data Source: STRINGDB
TGM1
Tchem
Family: Enzyme
Novelty: 0.00103799
Score: 0.923
Data Source: STRINGDB
SPRR1B
Tbio
Novelty: 0.0320028
Score: 0.922
Data Source: STRINGDB
FLG
Tbio
Novelty: 0.00072986
Score: 0.921
Data Source: STRINGDB
SPRR3
Tbio
Novelty: 0.0241484
Score: 0.913
Data Source: STRINGDB
SPRR2B
Tdark
Novelty: 0.36342019
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score  1138.82

PubMed score by year
PubTator Score  362.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer