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Tbio
PI3
Elafin

Protein Summary
Description
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243924
  • ENSP00000243924
  • ENSG00000124102

Symbol
  • WAP3
  • WFDC14
  • ESI
  • WAP3
  • SKALP
  • WFDC14
  • cementoin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
tissue sample
0.68
biological term
0.67
virus perturbation
0.64
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157.88   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157.88   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (297)
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.963
Data Source:  STRINGDB
CSTA
Tbio
Novelty:  0.00453121
Score:  0.947
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.942
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.939
Data Source:  STRINGDB
EVPL
Tbio
Novelty:  0.00274279
Score:  0.936
Data Source:  STRINGDB
TGM1
Tchem
Family:  Enzyme
Novelty:  0.00103799
Score:  0.923
Data Source:  STRINGDB
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.922
Data Source:  STRINGDB
FLG
Tbio
Novelty:  0.00072986
Score:  0.921
Data Source:  STRINGDB
SPRR3
Tbio
Novelty:  0.0241484
Score:  0.913
Data Source:  STRINGDB
SPRR2B
Tdark
Novelty:  0.36342019
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Developmental Biology
Formation of the cornified envelope
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
54.4
self reported educational attainment
1
1
1
13.4
mathematical ability
1
1
1
7.9
1
1
0
1.1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
54.4
self reported educational attainment
1
13.4
mathematical ability
1
7.9
0
1.1
3.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidase inhibitor 3
VGNC:6240
458276
Dog
peptidase inhibitor 3
VGNC:44516
477241
Horse
peptidase inhibitor 3
VGNC:21408
100056125
Cow
trappin 5
407163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidase inhibitor 3
Dog
peptidase inhibitor 3
Horse
peptidase inhibitor 3
Cow
trappin 5
Publication Statistics
PubMed Score 1157.88
PubMed score by year
PubTator Score 362.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title