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Tbio
FST
Follistatin

Protein Summary
Description
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256759
  • ENSP00000256759
  • ENSG00000134363
  • ENST00000396947
  • ENSP00000380151

Symbol
  • FS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
small molecule perturbation
0.88
transcription factor perturbation
0.8
transcription factor binding site profile
0.78
biological term
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1146.98   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 532   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1146.98   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
23.3
self reported educational attainment
1
1
1
15.6
glomerular filtration rate
2
1
2
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
23.3
self reported educational attainment
1
15.6
glomerular filtration rate
2
4.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follistatin
VGNC:4007
461879
Macaque
follistatin
707420
Mouse
MGI:95586
14313
Rat
RGD:2633
24373
Dog
follistatin
VGNC:51894
479336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follistatin
Macaque
follistatin
Mouse
Rat
Dog
follistatin
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (164)
Antagonism of Activin by Follistatin (R-HSA-2473224)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antagonism of Activin by Follistatin
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Antagonism of Activin by Follistatin
Signal Transduction
Signaling by Activin
Signaling by TGF-beta family members
Protein-Protein Interactions (154)
1 – 10 of 154
INHBA
Tbio
Novelty: 0.00657844
Score: 0.997
Data Source: Reactome,STRINGDB
MSTN
Tclin
Novelty: 0.00062316
Score: 0.99
Data Source: STRINGDB
INHBE
Tbio
Novelty: 0.07526145
Score: 0.987
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.984
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.982
Data Source: STRINGDB
BMP7
Tbio
Novelty: 0.00049424
Score: 0.982
Data Source: STRINGDB
INHBB
Tbio
Novelty: 0.0154773
Score: 0.969
Data Source: Reactome,STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.969
Data Source: STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.964
Data Source: STRINGDB
GDF11
Tclin
Novelty: 0.00585981
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  1146.98

PubMed score by year
PubTator Score  223.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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