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Tbio
NCF2
Neutrophil cytosol factor 2

Protein Summary
Description
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367535
  • ENSP00000356505
  • ENSG00000116701
  • ENST00000367536
  • ENSP00000356506
  • ENST00000413720
  • ENSP00000399294
  • ENST00000418089
  • ENSP00000407217

Symbol
  • NOXA2
  • P67PHOX
  • NCF-2
  • NOXA2
  • P67PHOX
  • P67-PHOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
protein domain
0.85
transcription factor perturbation
0.84
PubMedID
0.77
tissue sample
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.34   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.34   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
2
97.2
1
1
0
1.4
83.6
1
1
0
1.4
73.8
1
1
0
1.4
73.8
1
1
0
1.4
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
97.2
0
1.4
83.6
0
1.4
73.8
0
1.4
73.8
0
1.4
73.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neutrophil cytosolic factor 2
VGNC:1343
457573
Macaque
neutrophil cytosolic factor 2
715052
Mouse
MGI:97284
17970
Dog
neutrophil cytosolic factor 2
VGNC:43650
480036
Horse
neutrophil cytosolic factor 2
VGNC:20586
100051787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neutrophil cytosolic factor 2
Macaque
neutrophil cytosolic factor 2
Mouse
Dog
neutrophil cytosolic factor 2
Horse
neutrophil cytosolic factor 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19878-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cellular responses to external stimuli
Cellular responses to stress
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (171)
1 – 10 of 171
CAMSAP3
Tbio
Novelty: 0.04216784
p_int: 0.99999892
p_ni: 0.000001079
p_wrong: 2e-9
Score: 0.416
Data Source: BioPlex,STRINGDB
BPGM
Tbio
Family: Enzyme
Novelty: 0.03437401
p_int: 0.99966613
p_ni: 0.000333865
p_wrong: 5e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
TARDBP
Tbio
Novelty: 0.00165455
p_int: 0.999433409
p_ni: 0.000566589
p_wrong: 2e-9
Score: 0.288
Data Source: BioPlex,STRINGDB
USP47
Tchem
Family: Enzyme
Novelty: 0.07579226
p_int: 0.977296259
p_ni: 0.022703741
Data Source: BioPlex
TBC1D4
Tbio
Novelty: 0.00549202
p_int: 0.780546998
p_ni: 0.219453002
Score: 0.188
Data Source: BioPlex,STRINGDB
NCF1
Tbio
Novelty: 0.00120288
Score: 0.999
Data Source: Reactome,STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.998
Data Source: Reactome,STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.997
Data Source: Reactome,STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.989
Data Source: Reactome,STRINGDB
NCF4
Tbio
Novelty: 0.00560244
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  309.34

PubMed score by year
PubTator Score  158.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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