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Tbio
CXCL3
C-X-C motif chemokine 3

Protein Summary
Description
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296026
  • ENSP00000296026
  • ENSG00000163734

Symbol
  • GRO3
  • GROG
  • SCYB3
  • GRO3
  • GROg
  • MIP2B
  • SCYB3
  • MIP-2b
  • CINC-2b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
0.99
histone modification site profile
0.82
small molecule perturbation
0.79
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.4   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.4   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
4
5
98.1
myeloid white cell count
3
3
3
96.1
neutrophil percentage of leukocytes
2
2
2
90.2
lymphocyte percentage of leukocytes
2
2
2
89.7
leukocyte count
4
2
4
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
98.1
myeloid white cell count
3
96.1
neutrophil percentage of leukocytes
2
90.2
lymphocyte percentage of leukocytes
2
89.7
leukocyte count
4
89.3
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 3
VGNC:8662
461255
Mouse
MGI:108068
14825
Cow
chemokine (C-X-C motif) ligand 2
281214
Opossum
growth-regulated alpha protein
100023783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 3
Mouse
Cow
chemokine (C-X-C motif) ligand 2
Opossum
growth-regulated alpha protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19876-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (108)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (283)
1 – 10 of 283
CXCL2
Tbio
Novelty:  0.00201175
p_int:  0.999998522
p_wrong:  0.000001479
Score:  0.969
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.999967534
p_ni:  0.000032466
Data Source:  BioPlex
CXCL1
Tbio
Novelty:  0.00059123
p_int:  0.999862915
p_ni:  1e-9
p_wrong:  0.000137085
Score:  0.966
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.995917047
p_ni:  0.00408295
p_wrong:  3e-9
Data Source:  BioPlex
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.913759336
p_ni:  0.086240664
Data Source:  BioPlex
CXCR2
Tchem
Family:  GPCR
Novelty:  0.00108314
Score:  0.986
Data Source:  STRINGDB
CXCL5
Tbio
Novelty:  0.00286795
Score:  0.98
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.978
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.977
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.976
Data Source:  STRINGDB
Publication Statistics
PubMed Score  80.40

PubMed score by year
PubTator Score  57.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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