CXCL2
C-X-C motif chemokine 2
Protein Summary
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
- ENST00000508487
- ENSP00000427279
- ENSG00000081041
- GRO2
- GROB
- MIP2A
- SCYB2
- GRO2
- GROb
- MIP2
- MIP2A
- SCYB2
- MGSA-b
- MIP-2a
- CINC-2a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
gene perturbation | 1 | ||
virus perturbation | 1 | ||
small molecule perturbation | 0.89 | ||
histone modification site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 508.79 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 397 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 508.79 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 397 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0