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Tclin
NFKB1
Nuclear factor NF-kappa-B p105 subunit

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226574
  • ENSP00000226574
  • ENSG00000109320
  • ENST00000394820
  • ENSP00000378297
  • ENST00000505458
  • ENSP00000424790
  • ENST00000600343
  • ENSP00000469340

Symbol
  • p50
  • KBF1
  • p105
  • EBP-1
  • CVID12
  • NF-kB1
  • NFKB-p50
  • NFkappaB
  • NF-kappaB
  • NFKB-p105
  • NF-kappa-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
1
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 498.85   (req: < 5)
Gene RIFs: 2433   (req: <= 3)
Antibodies: 2189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 498.85   (req: >= 5)
Gene RIFs: 2433   (req: > 3)
Antibodies: 2189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (509)
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.999999949
p_ni:  5e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  0.999999796
p_ni:  2.01e-7
p_wrong:  3e-9
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
NFKBID
Tbio
Novelty:  0.04272718
p_int:  0.999999359
p_ni:  6.41e-7
Score:  0.835
Data Source:  BioPlex,STRINGDB
REL
Tbio
Family:  TF
Novelty:  0.00038265
p_int:  0.999999322
p_ni:  6.77e-7
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
RELB
Tbio
Family:  TF
Novelty:  0.00216805
p_int:  0.999998328
p_ni:  1e-8
p_wrong:  0.000001662
Score:  0.995
Data Source:  BioPlex,STRINGDB
PADI3
Tchem
Family:  Enzyme
Novelty:  0.01110139
p_int:  0.999727307
p_ni:  0.000272684
p_wrong:  8e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
NFYC
Tbio
Family:  TF
Novelty:  0.00626931
p_int:  0.989562356
p_ni:  0.010437626
p_wrong:  1.8e-8
Score:  0.322
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.968601355
p_ni:  0.031398643
p_wrong:  2e-9
Score:  0.429
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.943718437
p_ni:  0.056170683
p_wrong:  0.00011088
Data Source:  BioPlex
NOV
Tbio
Novelty:  0.00636744
p_int:  0.92598698
p_ni:  0.074012889
p_wrong:  1.31e-7
Score:  0.309
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
1 – 4 of 4
ROCK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ROCK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
Pathways (272)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
CLEC7A (Dectin-1) signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (60)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
4
98.1
lymphocyte percentage of leukocytes
2
3
3
87.6
neutrophil percentage of leukocytes
2
2
2
85.7
2
1
0
1.2
85.5
reticulocyte count
2
2
2
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
98.1
lymphocyte percentage of leukocytes
3
87.6
neutrophil percentage of leukocytes
2
85.7
0
1.2
85.5
reticulocyte count
2
84.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor kappa B subunit 1
VGNC:2972
461406
Macaque
nuclear factor kappa B subunit 1
710324
Mouse
MGI:97312
18033
Rat
RGD:70498
81736
Dog
nuclear factor kappa B subunit 1
VGNC:43780
442859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor kappa B subunit 1
Macaque
nuclear factor kappa B subunit 1
Mouse
Rat
Dog
nuclear factor kappa B subunit 1
Publication Statistics
PubMed Score 498.85
PubMed score by year
PubTator Score 10614.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title