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Tclin
NFKB1
Nuclear factor NF-kappa-B p105 subunit

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226574
  • ENSP00000226574
  • ENSG00000109320
  • ENST00000394820
  • ENSP00000378297
  • ENST00000505458
  • ENSP00000424790
  • ENST00000600343
  • ENSP00000469340

Symbol
  • p50
  • KBF1
  • p105
  • EBP-1
  • CVID12
  • NF-kB1
  • NFKB-p50
  • NFkappaB
  • NF-kappaB
  • NFKB-p105
  • NF-kappa-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
1
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.43   (req: < 5)
Gene RIFs: 2433   (req: <= 3)
Antibodies: 2189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.43   (req: >= 5)
Gene RIFs: 2433   (req: > 3)
Antibodies: 2189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
cepharanthine
chemical structure image
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.2
94.3
3
3
0
1
92.7
2
2
0
1.1
80.5
Oral ulcer
1
1
0
1
77.6
eosinophil count
3
1
3
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94.3
0
1
92.7
0
1.1
80.5
Oral ulcer
0
1
77.6
eosinophil count
3
76.6
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (272)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (509)
1 – 10 of 509
NFKBIA
Tchem
Novelty: 0.00022873
p_int: 0.999999949
p_ni: 5e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NFKBIB
Tbio
Novelty: 0.00517222
p_int: 0.999999796
p_ni: 2.01e-7
p_wrong: 3e-9
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
NFKBID
Tbio
Novelty: 0.04272718
p_int: 0.999999359
p_ni: 6.41e-7
Score: 0.835
Data Source: BioPlex,STRINGDB
REL
Tbio
Family: TF
Novelty: 0.00038265
p_int: 0.999999322
p_ni: 6.77e-7
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
RELB
Tbio
Family: TF
Novelty: 0.00216805
p_int: 0.999998328
p_ni: 1e-8
p_wrong: 0.000001662
Score: 0.995
Data Source: BioPlex,STRINGDB
PADI3
Tchem
Family: Enzyme
Novelty: 0.01110139
p_int: 0.999727307
p_ni: 0.000272684
p_wrong: 8e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
NFYC
Tbio
Family: TF
Novelty: 0.00626931
p_int: 0.989562356
p_ni: 0.010437626
p_wrong: 1.8e-8
Score: 0.322
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.968601355
p_ni: 0.031398643
p_wrong: 2e-9
Score: 0.429
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.943718437
p_ni: 0.056170683
p_wrong: 0.00011088
Data Source: BioPlex
NOV
Tbio
Novelty: 0.00636744
p_int: 0.92598698
p_ni: 0.074012889
p_wrong: 1.31e-7
Score: 0.309
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  482.43

PubMed score by year
PubTator Score  10614.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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