Tbio ITIH1 Inter-alpha-trypsin inhibitor heavy chain H1

Protein Summary

Description

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P19827
• A8K9N5
• B2RAH9
• B7Z558
• B7Z8C0
• F5H165
• F5H7Y8
• P78455
• Q01746
• Q562G1
• ITI heavy chain H1

Gene Name

• ITIH1

Ensembl ID

• ENST00000273283
• ENSP00000273283
• ENSG00000055957
• ENST00000537050
• ENSP00000443847

Symbol

• IGHEP1
• H1P
• ITIH
• SHAP
• IATIH
• IGHEP1
• ITI-HC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.65
disease perturbation	0.62
gene perturbation	0.56
cell line	0.55
transcription factor	0.53

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Inter-alpha-trypsin Inhibitor Heavy Chain H1

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Inter-alpha-trypsin Inhibitor Heavy Chain H1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.48   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 253   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.48   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0