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Tchem
AOC1
Amiloride-sensitive amine oxidase [copper-containing]

Protein Summary
Description
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360937
  • ENSP00000354193
  • ENSG00000002726
  • ENST00000416793
  • ENSP00000411613
  • ENST00000467291
  • ENSP00000418328
  • ENST00000493429
  • ENSP00000418614

Symbol
  • ABP1
  • DAO1
  • ABP
  • DAO
  • KAO
  • ABP1
  • DAO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
cell type or tissue
0.82
disease
0.75
chemical
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.57   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.57   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
pentamidine
chemical structure image
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
97.8
QT interval
3
3
0
1.5
89.6
body mass index
2
2
2
86.3
3
1
2
1.1
83.1
high density lipoprotein cholesterol measurement
4
2
4
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
97.8
QT interval
0
1.5
89.6
body mass index
2
86.3
2
1.1
83.1
high density lipoprotein cholesterol measurement
4
77.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amine oxidase, copper containing 1
VGNC:4264
107975990
Macaque
amine oxidase, copper containing 1
714112
Mouse
MGI:1923757
76507
Rat
RGD:61296
65029
Dog
amine oxidase, copper containing 1
VGNC:37947
475536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amine oxidase, copper containing 1
Macaque
amine oxidase, copper containing 1
Mouse
Rat
Dog
amine oxidase, copper containing 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19801-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Immune System
Innate Immune System
Metabolism
Neutrophil degranulation
Gene Ontology Terms (31)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (127)
1 – 10 of 127
HNMT
Tchem
Family: Enzyme
Novelty: 0.00100341
Score: 0.977
Data Source: STRINGDB
ODC1
Tclin
Family: Enzyme
Novelty: 0.00037968
Score: 0.972
Data Source: STRINGDB
HDC
Tbio
Family: Enzyme
Novelty: 0.00193646
Score: 0.972
Data Source: STRINGDB
SRM
Tchem
Family: Enzyme
Novelty: 0.01583759
Score: 0.97
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.964
Data Source: STRINGDB
AGMAT
Tbio
Family: Enzyme
Novelty: 0.03970349
Score: 0.953
Data Source: STRINGDB
SAT1
Tbio
Family: Enzyme
Novelty: 0.0022456
Score: 0.953
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.928
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.926
Data Source: STRINGDB
ALDH9A1
Tbio
Family: Enzyme
Novelty: 0.01688006
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  625.57

PubMed score by year
PubTator Score  1216.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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