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Tclin
RXRA
Retinoic acid receptor RXR-alpha

Protein Summary
Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000481739
  • ENSP00000419692
  • ENSG00000186350

Symbol
  • NR2B1
  • NR2B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
chemical
0.99
hub protein
0.99
biological process
0.98
kinase
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.24   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.24   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 213
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
4
10
95.4
appendicular lean mass
2
1
2
45.7
testosterone measurement
2
1
2
44.2
reticulocyte count
7
2
7
38.1
reticulocyte measurement
3
1
3
34.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
10
95.4
appendicular lean mass
2
45.7
testosterone measurement
2
44.2
reticulocyte count
7
38.1
reticulocyte measurement
3
34.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98214
20181
Rat
RGD:3610
25271
Dog
retinoid X receptor alpha
VGNC:45817
491278
Horse
retinoid X receptor alpha
VGNC:22639
100069096
Cow
retinoid X receptor alpha
VGNC:34230
507554
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
retinoid X receptor alpha
Horse
retinoid X receptor alpha
Cow
retinoid X receptor alpha
Protein Structure (83 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19793-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 83
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (91)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Bile acid and bile salt metabolism
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Bile acid and bile salt metabolism
Gene Ontology Terms (50)
Items per page:
10
1 – 10 of 22
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (327)
1 – 10 of 327
RXRG
Tclin
Family:  NR
Novelty:  0.01646377
p_int:  1
Score:  0.967
Data Source:  BioPlex,STRINGDB
RARA
Tclin
Family:  NR
Novelty:  0.00080574
Score:  0.998
Data Source:  Reactome,STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.997
Data Source:  Reactome,STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.997
Data Source:  Reactome,STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.997
Data Source:  Reactome,STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.997
Data Source:  Reactome,STRINGDB
THRB
Tclin
Family:  NR
Novelty:  0.0014797
Score:  0.995
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.992
Data Source:  Reactome,STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.991
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.989
Data Source:  STRINGDB
Publication Statistics
PubMed Score  314.24

PubMed score by year
PubTator Score  1599.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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