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Tchem
CSNK2A2
Casein kinase II subunit alpha'

Protein Summary
Description
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262506
  • ENSP00000262506
  • ENSG00000070770

Symbol
  • CK2A2
  • CK2A2
  • CSNK2A1
  • CK2alpha'
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.99
small molecule
0.98
kinase perturbation
0.97
transcription factor perturbation
0.97


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 477.66   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 477.66   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Chemical Tool
N-(2-((2-aminoethyl)(methyl)amino)-5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)phenyl)acetamide
image for N-(2-((2-aminoethyl)(methyl)amino)-5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)phenyl)acetamide
Details:
  • ChEBI: 143115
  • Provider: UNC-CH
  • Activity: 4.1 nM
  • Selectivity: 0.042
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
38
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
casein kinase 2 alpha 2
VGNC:8976
454131
Macaque
casein kinase 2 alpha 2
712455
Mouse
MGI:88547
13000
Rat
RGD:1306882
307641
Dog
casein kinase 2 alpha 2
VGNC:39670
478108
Species
Name
OMA
EggNOG
Inparanoid
Chimp
casein kinase 2 alpha 2
Macaque
casein kinase 2 alpha 2
Mouse
Rat
Dog
casein kinase 2 alpha 2
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19784-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (63)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Axon guidance
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Autophagy
Axon guidance
Cell Cycle
Cell Cycle, Mitotic
Cellular responses to external stimuli
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (242)
1 – 10 of 242
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 1
Score: 0.207
Data Source: BioPlex,STRINGDB
GPATCH2
Tdark
Novelty: 0.03284393
p_int: 1
Score: 0.178
Data Source: BioPlex,STRINGDB
GPATCH2L
Tdark
Novelty: 1.68490464
p_int: 0.999999999
p_ni: 1e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
PCGF5
Tdark
Novelty: 0.11370936
p_int: 0.999999998
p_ni: 2e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
NKAP
Tbio
Novelty: 0.04982584
p_int: 0.999999998
p_ni: 2e-9
Score: 0.664
Data Source: BioPlex,STRINGDB
PCGF3
Tbio
Novelty: 0.14226976
p_int: 0.999999912
p_ni: 6e-8
p_wrong: 2.8e-8
Score: 0.782
Data Source: BioPlex,STRINGDB
FBRS
Tbio
Novelty: 0.13646817
p_int: 0.999999878
p_ni: 1.22e-7
Score: 0.71
Data Source: BioPlex,STRINGDB
EIF3J
Tbio
Novelty: 0.04648652
p_int: 0.999999722
p_ni: 2.78e-7
Score: 0.542
Data Source: BioPlex,STRINGDB
PHRF1
Tbio
Family: Epigenetic
Novelty: 0.05250013
p_int: 0.999999695
p_ni: 3.05e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999999602
p_ni: 3.98e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  477.66

PubMed score by year
PubTator Score  251.14

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer