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Tbio
ORM2
Alpha-1-acid glycoprotein 2

Protein Summary
Description
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction. This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431067
  • ENSP00000394936
  • ENSG00000228278

Symbol
  • AGP2
  • AGP2
  • AGP-B
  • AGP-B'
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.92
hub protein
0.71
tissue
0.59
cell line
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.3   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.3   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
4
3
3
23.7
97.7
aspartate aminotransferase measurement
3
2
2
15.1
93
sex hormone-binding globulin measurement
4
1
4
78.6
apolipoprotein A 1 measurement
2
2
2
75
testosterone measurement
4
2
5
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
3
23.7
97.7
aspartate aminotransferase measurement
2
15.1
93
sex hormone-binding globulin measurement
4
78.6
apolipoprotein A 1 measurement
2
75
testosterone measurement
5
72.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alpha-1-acid glycoprotein 1
703984
Mouse
MGI:97444
18406
Mouse
MGI:97445
18407
Rat
RGD:67390
24614
Dog
alpha-1-acid glycoprotein 1
100685620
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alpha-1-acid glycoprotein 1
Mouse
Mouse
Rat
Dog
alpha-1-acid glycoprotein 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19652-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Platelet activation, signaling and aggregation
Gene Ontology Terms (15)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (260)
1 – 10 of 260
ORM1
Tbio
Novelty:  0.007451
p_int:  0.999999818
p_ni:  1.4e-8
p_wrong:  1.68e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999919686
p_ni:  0.000052456
p_wrong:  0.000027858
Score:  0.816
Data Source:  BioPlex,STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.989
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.97
Data Source:  STRINGDB
HP
Tbio
Novelty:  0.00016649
Score:  0.968
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.967
Data Source:  STRINGDB
TTR
Tclin
Novelty:  0.0001199
Score:  0.966
Data Source:  STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
Score:  0.965
Data Source:  STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.962
Data Source:  STRINGDB
HRG
Tbio
Novelty:  0.0027048
Score:  0.957
Data Source:  STRINGDB
Publication Statistics
PubMed Score  115.30

PubMed score by year
PubTator Score  57.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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