Tchem SLC9A1 Sodium/hydrogen exchanger 1

Protein Summary

Description

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P19634
• B1ALD6
• D3DPL4
• Q96EM2

Gene Name

• SLC9A1

Ensembl ID

• ENST00000263980
• ENSP00000263980
• ENSG00000090020
• ENST00000374086
• ENSP00000363199

Symbol

• APNH1
• NHE1
• APNH
• NHE1
• LIKNS
• NHE-1
• PPP1R143

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.99
kinase	0.93
transcription factor binding site profile	0.92
hub protein	0.88

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc9 Family Of Sodium/hydrogen Exchangers / Sodium/hydrogen Exchanger 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1133.38   (req: < 5)

Gene RIFs: 167   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1133.38   (req: >= 5)

Gene RIFs: 167   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 155

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (155)

Explore Active Ligands

1 – 10 of 155

ethylisopropylamiloride

SLC9A1Tchem Transporter

pKi : 6.38

CHEMBL2170635

SLC9A1Tchem Transporter

pIC50 : 7.75

CHEMBL2170606

SLC9A1Tchem Transporter

pIC50 : 7.55

CHEMBL2170629

SLC9A1Tchem Transporter

pIC50 : 7.62

CHEMBL2170611

SLC9A1Tchem Transporter

pIC50 : 8.3

CHEMBL3900457

SLC9A1Tchem Transporter

pIC50 : 8.7

CHEMBL3980085

SLC9A1Tchem Transporter

pIC50 : 9

CHEMBL3900790

SLC9A1Tchem Transporter

pIC50 : 9

CHEMBL392093

SLC9A1Tchem Transporter

pIC50 : 9.32

CHEMBL419578

SLC9A1Tchem Transporter

pIC50 : 8.52

Protein-Protein Interactions (155)

Explore Interacting Targets

1 – 10 of 155

• See Interactions on String-DB

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.999994569

p_ni:  0.000005431

Data Source:  BioPlex

IPPK

Tbio

Family:  Enzyme

Novelty:  0.02169701

p_int:  0.999951609

p_ni:  0.000048391

Data Source:  BioPlex

LPAR1

Tchem

Family:  GPCR

Novelty:  0.00318056

p_int:  0.999921045

p_ni:  0.000078955

Score:  0.225

Data Source:  BioPlex,STRINGDB

GALNT7

Tbio

Family:  Enzyme

Novelty:  0.05328171

p_int:  0.999841265

p_ni:  0.000157983

p_wrong:  7.52e-7

Score:  0.195

Data Source:  BioPlex,STRINGDB

AOC3

Tchem

Family:  Enzyme

Novelty:  0.00078739

p_int:  0.998846028

p_ni:  0.001153964

p_wrong:  9e-9

Score:  0.216

Data Source:  BioPlex,STRINGDB

SLC22A2

Tchem

Family:  Transporter

Novelty:  0.00439263

p_int:  0.99865291

p_ni:  0.001343018

p_wrong:  0.000004072

Data Source:  BioPlex

FNDC5

Tbio

Novelty:  0.0015827

p_int:  0.997422145

p_ni:  0.00257783

p_wrong:  2.5e-8

Score:  0.167

Data Source:  BioPlex,STRINGDB

SLCO6A1

Tbio

Family:  Transporter

Novelty:  0.07836028

p_int:  0.997331203

p_ni:  0.002668797

Score:  0.284

Data Source:  BioPlex,STRINGDB

CCDC107

Tdark

Novelty:  1.10682722

p_int:  0.988645345

p_ni:  0.011348838

p_wrong:  0.000005817

Data Source:  BioPlex

PTGIR

Tclin

Family:  GPCR

Novelty:  0.0091906

p_int:  0.986846112

p_ni:  0.013153887

p_wrong:  1e-9

Data Source:  BioPlex

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (2)

1 – 2 of 2

ROCK1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  3

1: Regulation of actin cytoskeleton

2: cAMP signaling pathway

3: Proteoglycans in cancer

ROCK2

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  3

1: Regulation of actin cytoskeleton

2: cAMP signaling pathway

3: Proteoglycans in cancer

Pathways (27)

Reactome (9)

KEGG (11)

PathwayCommons (4)

WikiPathways (3)

Glycosaminoglycan metabolism (R-HSA-1630316)

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1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Glycosaminoglycan metabolism	122 targets	R-HSA-1630316
Reactome	Hyaluronan metabolism	17 targets	R-HSA-2142845
Reactome	Hyaluronan uptake and degradation	12 targets	R-HSA-2160916
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of carbohydrates	293 targets	R-HSA-71387

Name	Explore in Pharos	Explore in Source
Glycosaminoglycan metabolism	122 targets	R-HSA-1630316
Hyaluronan metabolism	17 targets	R-HSA-2142845
Hyaluronan uptake and degradation	12 targets	R-HSA-2160916
Metabolism	2112 targets	R-HSA-1430728
Metabolism of carbohydrates	293 targets	R-HSA-71387

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (70)

Functions (10)

Components (19)

Processes (41)

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1 – 10 of 10

GO Term	Evidence	Assigned by
calcium-dependent protein binding	Inferred from Direct Assay (IDA)	UniProtKB
protein phosphatase 2B binding	Inferred from Direct Assay (IDA)	BHF-UCL
sodium:proton antiporter activity	Inferred from Direct Assay (IDA)	UniProtKB
potassium:proton antiporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylinositol-4,5-bisphosphate binding	Traceable Author Statement (TAS)	BHF-UCL
protein binding, bridging	Traceable Author Statement (TAS)	BHF-UCL
protein-containing complex scaffold activity	Traceable Author Statement (TAS)	BHF-UCL
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential	Traceable Author Statement (TAS)	BHF-UCL
solute:proton antiporter activity	Traceable Author Statement (TAS)	UniProtKB
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
leukocyte count	EFO_0004308	1	1	1		40.7
neutrophil count	EFO_0004833	1	1	1		14
IGF-1 measurement	EFO_0004627	1	1	1		9.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
leukocyte count	EFO_0004308	1		40.7
neutrophil count	EFO_0004833	1		14
IGF-1 measurement	EFO_0004627	1		9.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Antiport
Calmodulin-binding
Cell membrane
Complete proteome
Deafness
Disease mutation
Endoplasmic reticulum
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
IGF-1 measurement
leukocyte count
neutrophil count

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	solute carrier family 9 member A1 [Source:HGNC Symbol;Acc:HGNC:11071]
Mouse	solute carrier family 9 (sodium/hydrogen exchanger), member 1	MGI:102462	20544
Rat	solute carrier family 9 member A1	RGD:3718	24782
Dog	solute carrier family 9 member A1	VGNC:53473	478171
Horse	solute carrier family 9 member A1	VGNC:50767	100070959

Species	Name	OMA	EggNOG	Inparanoid
Macaque	solute carrier family 9 member A1 [Source:HGNC Symbol;Acc:HGNC:11071]
Mouse	solute carrier family 9 (sodium/hydrogen exchanger), member 1
Rat	solute carrier family 9 member A1
Dog	solute carrier family 9 member A1
Horse	solute carrier family 9 member A1

Publication Statistics

PubMed Score 1133.38

PubMed score by year

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PubTator Score 492.82

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Related Publications

Text Mined References (205)

GeneRif Annotations (167)

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PMID	Year	Title