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Tchem
SLC9A1
Sodium/hydrogen exchanger 1

Protein Summary
Description
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263980
  • ENSP00000263980
  • ENSG00000090020
  • ENST00000374086
  • ENSP00000363199

Symbol
  • APNH1
  • NHE1
  • APNH
  • NHE1
  • LIKNS
  • NHE-1
  • PPP1R143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
kinase
0.93
transcription factor binding site profile
0.92
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1203.91   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1203.91   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 155
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0