SLC9A1
Sodium/hydrogen exchanger 1
Protein Classes
Protein Summary
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]
- ENST00000263980
- ENSP00000263980
- ENSG00000090020
- ENST00000374086
- ENSP00000363199
- APNH1
- NHE1
- APNH
- NHE1
- LIKNS
- NHE-1
- PPP1R143
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.99 | ||
kinase | 0.93 | ||
transcription factor binding site profile | 0.92 | ||
hub protein | 0.88 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1115.98 (req: < 5)
Gene RIFs: 167 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1115.98 (req: >= 5)
Gene RIFs: 167 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 51
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 131
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (131)
1 – 10 of 131
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (27)
Reactome (9)
KEGG (11)
PathwayCommons (4)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glycosaminoglycan metabolism | ||||
Reactome | Hyaluronan metabolism | ||||
Reactome | Hyaluronan uptake and degradation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glycosaminoglycan metabolism | ||||
Hyaluronan metabolism | ||||
Hyaluronan uptake and degradation | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Gene Ontology Terms (70)
Functions (10)
Components (19)
Processes (41)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (155)
1 – 10 of 155
LRRC55
Family: IC
Novelty: 0.25121277
p_int: 0.999994569
p_ni: 0.000005431
Data Source: BioPlex
IPPK
Family: Enzyme
Novelty: 0.02169701
p_int: 0.999951609
p_ni: 0.000048391
Data Source: BioPlex
LPAR1
Family: GPCR
Novelty: 0.00318056
p_int: 0.999921045
p_ni: 0.000078955
Score: 0.225
Data Source: BioPlex,STRINGDB
GALNT7
Family: Enzyme
Novelty: 0.05328171
p_int: 0.999841265
p_ni: 0.000157983
p_wrong: 7.52e-7
Score: 0.195
Data Source: BioPlex,STRINGDB
AOC3
Family: Enzyme
Novelty: 0.00078739
p_int: 0.998846028
p_ni: 0.001153964
p_wrong: 9e-9
Score: 0.216
Data Source: BioPlex,STRINGDB
SLC22A2
Family: Transporter
Novelty: 0.00439263
p_int: 0.99865291
p_ni: 0.001343018
p_wrong: 0.000004072
Data Source: BioPlex
FNDC5
Novelty: 0.0015827
p_int: 0.997422145
p_ni: 0.00257783
p_wrong: 2.5e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
SLCO6A1
Family: Transporter
Novelty: 0.07836028
p_int: 0.997331203
p_ni: 0.002668797
Score: 0.284
Data Source: BioPlex,STRINGDB
CCDC107
Novelty: 1.10682722
p_int: 0.988645345
p_ni: 0.011348838
p_wrong: 0.000005817
Data Source: BioPlex
PTGIR
Family: GPCR
Novelty: 0.0091906
p_int: 0.986846112
p_ni: 0.013153887
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score 1115.98
PubMed score by year
PubTator Score 492.82
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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