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Tchem
SLC9A1
Sodium/hydrogen exchanger 1

Protein Summary
Description
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263980
  • ENSP00000263980
  • ENSG00000090020
  • ENST00000374086
  • ENSP00000363199

Symbol
  • APNH1
  • NHE1
  • APNH
  • NHE1
  • LIKNS
  • NHE-1
  • PPP1R143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
kinase
0.93
transcription factor binding site profile
0.92
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1133.38   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1133.38   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 155
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (155)
ethylisopropylamiloride
Rendered image for ethylisopropylamiloride
CHEMBL2170635
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CHEMBL2170606
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CHEMBL2170629
Rendered image for CHEMBL2170629
CHEMBL2170611
Rendered image for CHEMBL2170611
CHEMBL3900457
Rendered image for CHEMBL3900457
CHEMBL3980085
Rendered image for CHEMBL3980085
CHEMBL3900790
Rendered image for CHEMBL3900790
CHEMBL392093
Rendered image for CHEMBL392093
CHEMBL419578
Rendered image for CHEMBL419578
Protein-Protein Interactions (155)
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.999994569
p_ni:  0.000005431
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.999951609
p_ni:  0.000048391
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999921045
p_ni:  0.000078955
Score:  0.225
Data Source:  BioPlex,STRINGDB
GALNT7
Tbio
Family:  Enzyme
Novelty:  0.05328171
p_int:  0.999841265
p_ni:  0.000157983
p_wrong:  7.52e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
p_int:  0.998846028
p_ni:  0.001153964
p_wrong:  9e-9
Score:  0.216
Data Source:  BioPlex,STRINGDB
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.99865291
p_ni:  0.001343018
p_wrong:  0.000004072
Data Source:  BioPlex
FNDC5
Tbio
Novelty:  0.0015827
p_int:  0.997422145
p_ni:  0.00257783
p_wrong:  2.5e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
p_int:  0.997331203
p_ni:  0.002668797
Score:  0.284
Data Source:  BioPlex,STRINGDB
CCDC107
Tdark
Novelty:  1.10682722
p_int:  0.988645345
p_ni:  0.011348838
p_wrong:  0.000005817
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.986846112
p_ni:  0.013153887
p_wrong:  1e-9
Data Source:  BioPlex
Pathways (27)
Glycosaminoglycan metabolism (R-HSA-1630316)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan metabolism
Reactome
Hyaluronan uptake and degradation
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Hyaluronan metabolism
Hyaluronan uptake and degradation
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (70)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
40.7
neutrophil count
1
1
1
14
IGF-1 measurement
1
1
1
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
40.7
neutrophil count
1
14
IGF-1 measurement
1
9.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 9 member A1 [Source:HGNC Symbol;Acc:HGNC:11071]
Mouse
MGI:102462
20544
Rat
RGD:3718
24782
Dog
solute carrier family 9 member A1
VGNC:53473
478171
Horse
solute carrier family 9 member A1
VGNC:50767
100070959
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 9 member A1 [Source:HGNC Symbol;Acc:HGNC:11071]
Mouse
Rat
Dog
solute carrier family 9 member A1
Horse
solute carrier family 9 member A1
Publication Statistics
PubMed Score 1133.38
PubMed score by year
PubTator Score 492.82
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title