You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EN2
Homeobox protein engrailed-2

Protein Summary
Description
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297375
  • ENSP00000297375
  • ENSG00000164778
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.75
microRNA
0.69
transcription factor
0.68
PubMedID
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.54   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.54   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-cytomegalovirus IgG measurement
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-cytomegalovirus IgG measurement
1
2.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
engrailed homeobox 2
VGNC:14000
742707
Mouse
MGI:95390
13799
Rat
RGD:1561842
499964
Dog
engrailed homeobox 2
VGNC:51801
611369
Horse
engrailed homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3343]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
engrailed homeobox 2
Mouse
Rat
Dog
engrailed homeobox 2
Horse
engrailed homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3343]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19622-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
Name
Explore in Pharos
Explore in Source
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Protein-Protein Interactions (65)
1 – 10 of 65
TLE1
Tbio
Novelty: 0.00594261
p_int: 0.999999539
p_ni: 3.04e-7
p_wrong: 1.57e-7
Score: 0.356
Data Source: BioPlex,STRINGDB
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.802
Data Source: STRINGDB
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
Score: 0.796
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.777
Data Source: STRINGDB
EGR2
Tbio
Family: TF
Novelty: 0.00215433
Score: 0.765
Data Source: STRINGDB
PNMT
Tchem
Family: Enzyme
Novelty: 0.00178141
Score: 0.753
Data Source: STRINGDB
FGF8
Tbio
Novelty: 0.00155113
Score: 0.71
Data Source: STRINGDB
PAX2
Tbio
Family: TF
Novelty: 0.00160808
Score: 0.689
Data Source: STRINGDB
ZNF224
Tbio
Family: TF
Novelty: 0.05381083
Score: 0.684
Data Source: STRINGDB
DHH
Tbio
Novelty: 0.00329784
Score: 0.665
Data Source: STRINGDB
Publication Statistics
PubMed Score  207.54

PubMed score by year
PubTator Score  93.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: