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Tbio
WT1
Wilms tumor protein

Protein Summary
Description
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379079
  • ENSP00000368370
  • ENSG00000184937
  • ENST00000530998
  • ENSP00000435307

Symbol
  • GUD
  • AWT1
  • WAGR
  • WT33
  • NPHS4
  • WIT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.98
phenotype
0.86
molecular function
0.84
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3580.57   (req: < 5)
Gene RIFs: 624   (req: <= 3)
Antibodies: 1029   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3580.57   (req: >= 5)
Gene RIFs: 624   (req: > 3)
Antibodies: 1029   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0