Tbio WT1 Wilms tumor protein

Protein Summary

Description

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

Uniprot Accession IDs

• P19544
• A8K6S1
• B3KSA5
• Q15881
• Q16256
• Q16575
• Q4VXV4
• Q4VXV5
• Q4VXV6
• Q8IYZ5

Gene Name

• WT1

Ensembl ID

• ENST00000379079
• ENSP00000368370
• ENSG00000184937
• ENST00000530998
• ENSP00000435307

Symbol

• GUD
• AWT1
• WAGR
• WT33
• NPHS4
• WIT-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	0.98
phenotype	0.86
molecular function	0.84
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Wilms Tumor Protein

Protein / Transcription Factor / Transcription Cofactor / Wilms Tumor Protein

Protein / Nucleic Acid Binding / Dna Binding Protein / Wilms Tumor Protein

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Wilms Tumor Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3580.57   (req: < 5)

Gene RIFs: 628   (req: <= 3)

Antibodies: 1029   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3580.57   (req: >= 5)

Gene RIFs: 628   (req: > 3)

Antibodies: 1029   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0