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Tbio
TFE3
Transcription factor E3

Protein Summary
Description
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRC ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315869
  • ENSP00000314129
  • ENSG00000068323
  • ENST00000493583
  • ENSP00000476976

Symbol
  • BHLHE33
  • TFEA
  • RCCP2
  • RCCX1
  • bHLHe33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
cell type or tissue
0.82
transcription factor binding site profile
0.77
kinase perturbation
0.71
transcription factor
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.21   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 386   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.21   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transcription factor binding to IGHM enhancer 3
712161
Mouse
MGI:98511
209446
Rat
RGD:1559642
317376
Dog
transcription factor binding to IGHM enhancer 3
VGNC:47293
491872
Horse
transcription factor binding to IGHM enhancer 3
VGNC:24038
100051983
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transcription factor binding to IGHM enhancer 3
Mouse
Rat
Dog
transcription factor binding to IGHM enhancer 3
Horse
transcription factor binding to IGHM enhancer 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19532-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Renal cell carcinoma
KEGG
Mitophagy - animal
KEGG
Transcriptional misregulation in cancer
Name
Explore in Pharos
Explore in Source
Renal cell carcinoma
Mitophagy - animal
Transcriptional misregulation in cancer
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
TFEB
Tbio
Family: TF
Novelty: 0.00248413
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00094044
p_int: 0.999999996
p_ni: 4e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
E2F3
Tbio
Family: TF
Novelty: 0.00287552
Score: 0.954
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.952
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.945
Data Source: STRINGDB
PTGDR
Tclin
Family: GPCR
Novelty: 0.00095153
Score: 0.908
Data Source: STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02026858
Score: 0.904
Data Source: STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
Score: 0.838
Data Source: STRINGDB
PRCC
Tbio
Novelty: 0.00836323
Score: 0.804
Data Source: STRINGDB
FLCN
Tbio
Novelty: 0.0022007
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score  450.21

PubMed score by year
PubTator Score  296.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer