FUT1
Galactoside 2-alpha-L-fucosyltransferase 1
Protein Summary
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016]
- ENST00000310160
- ENSP00000312021
- ENSG00000174951
- ENST00000645652
- ENSP00000494643
- H
- HSC
- H
- HH
- HSC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.79 | ||
cellular component | 0.77 | ||
small molecule perturbation | 0.57 | ||
tissue sample | 0.56 | ||
pathway | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 200.62 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 200.62 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0