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Tbio
FUT1
Galactoside 2-alpha-L-fucosyltransferase 1

Protein Summary
Description
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310160
  • ENSP00000312021
  • ENSG00000174951
  • ENST00000645652
  • ENSP00000494643

Symbol
  • H
  • HSC
  • H
  • HH
  • HSC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
cellular component
0.77
small molecule perturbation
0.57
tissue sample
0.56
pathway
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.94   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.94   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
2
1
2
56.6
albuminuria
2
1
2
48.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
2
56.6
albuminuria
2
48.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 1
VGNC:6624
468947
Macaque
fucosyltransferase 1 (H blood group)
718252
Mouse
MGI:109375
14343
Rat
RGD:2638
81919
Cow
fucosyltransferase 1
VGNC:49145
281174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 1
Macaque
fucosyltransferase 1 (H blood group)
Mouse
Rat
Cow
fucosyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19526-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
ABO blood group biosynthesis (R-HSA-9033807)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABO blood group biosynthesis
Reactome
Blood group systems biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
ABO blood group biosynthesis
Blood group systems biosynthesis
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (117)
1 – 10 of 117
GLT8D2
Tbio
Family: Enzyme
Novelty: 0.79488367
p_int: 0.998741657
p_ni: 0.000831545
p_wrong: 0.000426798
Score: 0.167
Data Source: BioPlex,STRINGDB
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.998717071
p_ni: 0.001282929
Score: 0.173
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.996327771
p_ni: 0.003473646
p_wrong: 0.000198583
Data Source: BioPlex
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.996087467
p_ni: 0.003912531
p_wrong: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.991663958
p_ni: 0.008334505
p_wrong: 0.000001537
Score: 0.54
Data Source: BioPlex,STRINGDB
HTRA1
Tbio
Family: Enzyme
Novelty: 0.0016879
p_int: 0.976165872
p_ni: 0.005369541
p_wrong: 0.018464588
Score: 0.177
Data Source: BioPlex,STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
p_int: 0.974329454
p_ni: 0.016181115
p_wrong: 0.00948943
Data Source: BioPlex
GLB1L2
Tdark
Family: Enzyme
Novelty: 1.03866932
p_int: 0.969626998
p_ni: 0.030373002
Data Source: BioPlex
UGT8
Tbio
Family: Enzyme
Novelty: 0.02518383
p_int: 0.968397745
p_ni: 0.031602255
p_wrong: 1e-9
Score: 0.273
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.945108918
p_ni: 0.054249134
p_wrong: 0.000641949
Score: 0.663
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  173.94

PubMed score by year
PubTator Score  312.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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