You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EIF2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

Protein Summary
Description
IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233057
  • ENSP00000233057
  • ENSG00000055332
  • ENST00000395127
  • ENSP00000378559
  • ENST00000405334
  • ENSP00000385014
  • ENST00000647926
  • ENSP00000497534

Symbol
  • PKR
  • PRKR
  • PKR
  • PRKR
  • EIF2AK1
  • PPP1R83
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
virus perturbation
1
molecular function
0.99
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.05   (req: < 5)
Gene RIFs: 261   (req: <= 3)
Antibodies: 1083   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.05   (req: >= 5)
Gene RIFs: 261   (req: > 3)
Antibodies: 1083   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0