You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EIF2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

Protein Summary
Description
IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233057
  • ENSP00000233057
  • ENSG00000055332
  • ENST00000395127
  • ENSP00000378559
  • ENST00000405334
  • ENSP00000385014
  • ENST00000647926
  • ENSP00000497534

Symbol
  • PKR
  • PRKR
  • PKR
  • PRKR
  • EIF2AK1
  • PPP1R83
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
virus perturbation
1
molecular function
0.99
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.12   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1083   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.12   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1083   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
25.4
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Host Interactions with Influenza Factors
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Disease
Host Interactions with Influenza Factors
ISG15 antiviral mechanism
Gene Ontology Terms (42)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (188)
1 – 10 of 188
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.999667879
p_ni: 0.00030251
p_wrong: 0.000029612
Data Source: BioPlex
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.996462269
p_ni: 0.003332617
p_wrong: 0.000205115
Score: 0.181
Data Source: BioPlex,STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
p_int: 0.828152649
p_ni: 0.002659238
p_wrong: 0.169188114
Data Source: BioPlex
IQCF1
Tdark
Novelty: 0.78525464
p_int: 0.827875107
p_ni: 0.003687752
p_wrong: 0.168437141
Score: 0.163
Data Source: BioPlex,STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.800475307
p_ni: 0.001054162
p_wrong: 0.198470531
Score: 0.185
Data Source: BioPlex,STRINGDB
TAB2
Tbio
Family: Enzyme
Novelty: 0.00635786
Score: 0.993
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.993
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.991
Data Source: STRINGDB
PRKRA
Tbio
Family: Kinase
Novelty: 0.02115618
Score: 0.99
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.12

PubMed score by year
PubTator Score  748.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: