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Tbio
TRIM21
E3 ubiquitin-protein ligase TRIM21

Protein Summary
Description
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of I ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254436
  • ENSP00000254436
  • ENSG00000132109

Symbol
  • RNF81
  • RO52
  • SSA1
  • SSA
  • RO52
  • SSA1
  • RNF81
  • Ro/SSA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
protein complex
1
protein domain
1
virus perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1190.66   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1190.66   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (483)
1 – 10 of 483
TROVE2
Tbio
Novelty: 0.00449966
Score: 0.993
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.978
Data Source: STRINGDB
DDX41
Tbio
Family: Enzyme
Novelty: 0.00021331
Score: 0.97
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00132895
Score: 0.969
Data Source: STRINGDB
IRF8
Tbio
Family: TF
Novelty: 0.00381715
Score: 0.965
Data Source: STRINGDB
IRF5
Tbio
Family: TF
Novelty: 0.00421869
Score: 0.963
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00827182
Score: 0.958
Data Source: STRINGDB
PML
Tbio
Novelty: 0.0021939
Score: 0.956
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00375288
Score: 0.953
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00375288
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  1190.66

PubMed score by year
PubTator Score  1017.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer